Representation of Auditory and Vocal Activity in the Amygdala

杏仁核听觉和发声活动的表征

• 批准号: 7472637
• 负责人: JAGMEET S. KANWAL
• 金额: $ 22.68万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7472637
• 关键词: Acoustics; Adaptive Behaviors; Affect; Affective; Aggressive behavior; Almond Nut; Amygdaloid structure; Animals; Anterior; Area; Auditory; Auditory area; Auditory system; Basal Ganglia; Behavioral; Biological Neural Networks; Brain; Brain Stem; Cell Nucleus; Cells; Chiroptera; Communication; Complex; Condition; Crying; Cues; Darkness; Data; Defect; Disease; Echolocation; Emotional; Emotions; Face; Frequencies; Grouping; Human; Individual; Lateral; Learning; Libraries; Life; Localized; Loudness; Maps; Medial; Memory; Modeling; Monkeys; Motivation; Neurons; Nuclear; PAG gene; Pain; Pathway interactions; Pattern; Personal Satisfaction; Physiologic pulse; Play; Procedures; Production; Prosencephalon; Public Health; Pulse taking; Punishment; Regulation; Research; Rewards; Role; Shapes; Site; Social Behavior; Social Interaction; Specificity; Speech; Stimulus; Structure; Stuttering; Temporal Lobe; Testing; Thalamic structure; Time; Variant; autism spectrum disorder; aversive conditioning; base; conditioned fear; frontal lobe; human PAG protein; receptive field; relating to nervous system; response; segregation; sensory cortex; sexual dimorphism; social; social communication; sound; vocalization

DESCRIPTION (provided by applicant): Audiovocal organization in the amygdala forms the neural substrate for adaptive behaviors that include motivational and affective regulation of vocal activity. The first objective of this project is to describe the representation of social calls in the basolateral amygdala. A second objective is to localize the interface between call representation and vocal expression in the amygdala. At present, we know very little of this organization in the mammalian amygdala. The proposed studies will be conducted in mustached bats since this species is highly social and vocal. The auditory system of this species is well developed and well studied. Local field potential recordings combined with single unit recordings from the amygdala will reveal the spatial organization for representing different call types including pitch-shifted call variants. Using statistical procedures, the auditory representation will be tested for an acoustic structure versus motivational value based match. A motivational-value based representation will allow for an aggressive versus affiliative grouping of neurons, whereas an acoustic structure-based organization will conform to the segregation of auditory and/or vocal activity according to acoustic features, e.g., fundamental frequency, pitch, loudness and/or direction of frequency modulations. Call selectivity will also be quantified along the dorso-ventral (lateral to basal nuclei) trajectory at several planes along the anterior-posterior axis within the basolateral amygdala. An acoustic structure to motivational value transformation is expected in auditory-to-vocal mappings within the basolateral amygdala. Therefore, at the end of each recording session, electrical microstimulation will be performed to reveal the patterns of vocal activity represented within the amygdala. Taken together, these data will reveal for the first time whether audiovocal learning and memory, e.g., via fear-conditioning, is embedded within a contingency/motivational-value (reward or pain) based and/or an acoustic- structure based frame-of-reference within the amygdala. PUBLIC HEALTH RELEVANCE The proposed research will elucidate the functional organization of the neural substrate within the amygdala for nonverbal audiovocal communication, including the vocal expression of affect and the prosodic content in speech. This research will identify the neural signatures for the representation of affiliative versus aggressive calls. The new findings have the potential to help us understand and resolve the neural defects in communication-related social disorders, e.g., stuttering and autism-spectrum disorders.

描述（由申请人提供）：杏仁核中的听声组织形成了适应性行为的神经基础，包括声音活动的动机和情感调节。该项目的第一个目标是描述基底外侧杏仁核中社交呼唤的表征。第二个目标是定位杏仁核中呼叫表示和声音表达之间的接口。目前，我们对哺乳动物杏仁核中的这个组织知之甚少。拟议的研究将在小胡子蝙蝠中进行，因为该物种具有高度的社会性和发声能力。该物种的听觉系统非常发达并且经过充分研究。局部场电位记录与杏仁核的单个单元记录相结合，将揭示代表不同呼叫类型（包括变调呼叫变体）的空间组织。使用统计程序，将测试听觉表征的声学结构与基于动机价值的匹配。基于动机价值的表示将允许神经元的攻击性与附属性分组，而基于声学结构的组织将根据声学特征（例如基频、音调、响度和声音）符合听觉和/或声音活动的分离。 /或频率调制的方向。呼叫选择性也将沿着基底外侧杏仁核内的前后轴的几个平面上的背腹侧（基底核的侧面）轨迹进行量化。基底外侧杏仁核内的听觉到声音映射预计会出现声学结构到动机价值的转换。因此，在每次录音结束时，将进行电微刺激以揭示杏仁核内代表的声音活动模式。总而言之，这些数据将首次揭示声乐学习和记忆（例如通过恐惧调节）是否嵌入基于偶然性/动机价值（奖励或痛苦）和/或基于声学结构的框架中。 -杏仁核内的参考。公共健康相关性拟议的研究将阐明杏仁核内用于非语言听觉交流的神经基质的功能组织，包括情感的声音表达和言语中的韵律内容。这项研究将确定代表亲和与攻击性呼叫的神经特征。新发现有可能帮助我们理解和解决与沟通相关的社会障碍（例如口吃和自闭症谱系障碍）中的神经缺陷。