Determinants of Pulmonary Endothelial Cell Function Conf

肺内皮细胞功能的决定因素

• 批准号: 6707800
• 负责人: Troy Stevens
• 金额: $ 2.63万
• 依托单位: UNIVERSITY OF SOUTH ALABAMA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6707800
• 关键词: cell component structure /function; gene expression; meeting /conference /symposium; pulmonary circulation; travel; vascular endothelium

DESCRIPTION (provided by applicant): Emerging evidence intimates that lung macro- and microvascular endothelial cells arise from distinct embryological (e.g. epigenetic) origins and, further, that these cells remain differentiated throughout embryonic, fetal and adult life. Thus, macro- and microvascular endothelial cell phenotype is controlled by both epigenetic and environmental factors. Interplay between epigenetic and environmental control of cell phenotype is poorly understood, and the clinical implications of such phenotype regulation have only recently been considered. Thus, this application seeks funding to support the 2004 Grover Conference on the Pulmonary Circulation, entitled Genetic and Environmental Determinants of Pulmonary Endothelial Cell Function, to assess the interplay between epigenetic and environmental regulation of endothelial cell phenotype. Specifically, the 2004 Grover Conference seeks to provide a forum for experts in endothelial cell and vascular biology to rigorously address: (1) The epigenetic origin of macro- and microvascular endothelial cells; (2) Control of cell function through activation of unique signaling networks in phenotypically distinct endothelia; (3) Endothelial cell plasticity; and, (4) Endothelium as a therapeutic target in medicine. Proceedings from this meeting will be disseminated as a special book edition, published by Futura. We request funding for partial support of travel and lodging for speakers. The 2004 Grover Conference will be the 12th in this series, representing the longest-standing conference on the Pulmonary Circulation, and will be held at the Lost Valley Ranch in Sedalia, Colorado. As in earlier formats, equal time will be given to presentation and discussion to optimize scientific interchange among experts in the field. At the conclusion of this meeting and as part of the published report, we will have identified areas of need for future investigation in lung vascular biology.

描述（由申请人提供）：新出现的证据表明，肺大血管内皮细胞和微血管内皮细胞源自不同的胚胎学（例如表观遗传）起源，并且这些细胞在整个胚胎、胎儿和成人生命中保持分化。因此，大血管和微血管内皮细胞表型受表观遗传和环境因素控制。人们对细胞表型的表观遗传和环境控制之间的相互作用知之甚少，并且这种表型调节的临床意义直到最近才被考虑。因此，本申请寻求资金支持 2004 年格罗弗肺循环会议，题为“肺内皮细胞功能的遗传和环境决定因素”，以评估内皮细胞表型的表观遗传和环境调节之间的相互作用。具体来说，2004年格罗弗会议旨在为内皮细胞和血管生物学专家提供一个论坛，严格讨论：（1）大血管内皮细胞和微血管内皮细胞的表观遗传起源； (2) 通过激活表型不同的内皮细胞中独特的信号网络来控制细胞功能； (3)内皮细胞的可塑性； (4) 内皮细胞作为医学治疗靶点。本次会议的记录将作为特别书籍版本传播，由 Futura 出版。我们请求资金为演讲者提供部分旅行和住宿支持。 2004 年 Grover 会议将是该系列的第 12 次会议，代表了历史最悠久的肺循环会议，并将在科罗拉多州锡代利亚的 Lost Valley Ranch 举行。与早期的形式一样，将给予演示和讨论相同的时间，以优化该领域专家之间的科学交流。在本次会议结束时，作为已发表报告的一部分，我们将确定肺血管生物学未来研究需要的领域。