Post-transcriptional Control of Gene Expression: Mechanisms of mRNA Decay

基因表达的转录后控制：mRNA 衰变机制

• 批准号: 7113502
• 负责人: Allan S Jacobson
• 金额: $ 3.44万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7113502
• 关键词: biological signal transduction; gene expression; genetic transcription; meeting /conference /symposium; messenger RNA; travel

DESCRIPTION (provided by applicant): We are requesting partial support for a FASEB Conference on "Post-Transcriptional Regulation of Gene Expression: Mechanisms of mRNA Decay", to be held in Snowmass Village, CO on June 24-29, 2006. Turnover of mRNA is a key, but frequently unrecognized, regulator of gene expression. The stability of an mRNA dictates its ultimate steady-state level. Programmed instability is an important mechanism of repressing gene expression, and the surveillance of mRNA quality ensures that only "fit" transcripts exit the nucleus and are translated, while RNA interference relies on selective mRNA turnover for its biological consequences, whereas novel pharmaceuticals are targeting mRNA decay pathways. For these reasons, mRNA turnover is attracting heightened interest from all areas of the life sciences. The proposed FASEB Conference is unique in concentrating on mRNA decay, thereby exploring in diverse biological settings the mechanisms, both at the cellular and molecular levels that underpin this universal process. The proposed meeting is particularly noteworthy in attracting investigators who study both prokaryotic and eukaryotic organisms, and in focusing on mechanisms by which RNAs interact with the decay apparatus, the translation apparatus, and the factors which modulate decay. The meeting's sessions will address decay events specific for mRNA 5' or 3' termini and their subcellular localization; structure/function relationships in RNA binding proteins, small RNAs, and other decay factors; the interplay of mRNA decay with the processes of translation and transcription; RNA quality control and related regulatory networks; and the clinical and pharmaceutical relevance of mRNA decay. It is anticipated that the presentations at the meeting will include the first public disclosures of several key structures and mechanisms, as well as provide novel insights for the regulation of growth, development, and disease. In short, the conference will provide an overview of the latest progress in an exciting field and will propel the next stage of its development.

描述（由申请人提供）：我们请求对将于 2006 年 6 月 24-29 日在科罗拉多州斯诺马斯村举行的“基因表达转录后调控：mRNA 衰变机制”的 FASEB 会议提供部分支持。 mRNA 是基因表达的关键调节因子，但常常未被认识到。 mRNA 的稳定性决定了其最终的稳态水平。 程序性不稳定性是抑制基因表达的重要机制，对 mRNA 质量的监控可确保只有“适合”的转录物离开细胞核并进行翻译，而 RNA 干扰则依赖于选择性 mRNA 周转来实现其生物学后果，而新型药物则以 mRNA 为目标衰变途径。 由于这些原因，mRNA 周转引起了生命科学各个领域的高度关注。 拟议的 FASEB 会议的独特之处在于专注于 mRNA 衰减，从而在不同的生物环境中探索支撑这一普遍过程的细胞和分子水平的机制。 拟议的会议特别值得注意的是，它吸引了研究原核和真核生物的研究人员，并重点关注 RNA 与衰变装置、翻译装置以及调节衰变因素相互作用的机制。 会议的会议将讨论 mRNA 5' 或 3' 末端特异的衰变事件及其亚细胞定位； RNA 结合蛋白、小 RNA 和其他衰减因子的结构/功能关系； mRNA 衰变与翻译和转录过程的相互作用； RNA质量控制和相关监管网络；以及 mRNA 衰减的临床和药物相关性。 预计会议上的演讲将包括首次公开披露几个关键结构和机制，并为生长、发育和疾病的调节提供新颖的见解。 简而言之，会议将概述这一令人兴奋的领域的最新进展，并将推动其下一阶段的发展。