Training in Cell Signaling and Lung Pathobiology

细胞信号传导和肺部病理学培训

• 批准号: 9061755
• 负责人: Troy Stevens
• 金额: $ 21.26万
• 依托单位: UNIVERSITY OF SOUTH ALABAMA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9061755
• 关键词: Lung; Signal Transduction; Training

DESCRIPTION (provided by applicant): This renewal application requests continued support for the predoctoral/short-term training program in "Cell signaling and lung pathobiology" based in the Center for Lung Biology at the University of South Alabama College of Medicine. As the predoctoral component of our training program matured through the first cycle of funding (2004-2009), we added short-term training in the second cycle (2009-2014) to support summer research experiences. Given our success with training, in this renewal application we request continued support for both predoctoral trainees (6 slots) and medical student trainees in short term summer research (4 slots). Research areas for training include mechanisms underlying pulmonary vasoconstriction and vascular remodeling in pulmonary hypertension, vascular and airway smooth muscle biology, regulation of lung endothelial barrier function, acute lung injury, mitochondrial function and signaling in oxidant stress, and involvement of ion channels in airway epithelium and vascular endothelium function. Our program, which continues to be one of only three in the southern US providing predoctoral training in lung research, will be co- directed by Drs. Mary Townsley and Troy Stevens, in consultation with an Internal Advisory Committee and annual review by distinguished External Advisors. The overall construct of the training program is based upon the strong emphasis by NIH and other national science leadership groups on broad, interdisciplinary training. The infrastructure for our predoctoral training program is provided by an interdisciplinary core curriculum in the Basic Medical Sciences Ph.D. program. Predoctoral trainees will be supported by the T32 for 2-3 years. These trainees commit to the lung biology track, identify a mentor from among the program faculty and complete a rigorous didactic advanced curriculum in signaling, biostatistics/experimental design, and lung biology/pathobiology. In addition to formal academic coursework, predoctoral trainees will participate in seminars and the Research-in-Progress journal club, as well as outstanding career survival skills training organized by the Center for Lung Biology. Short-term trainees enter a long-standing well-organized summer research program for medical students. These trainees will complete a 10-week research project focused on lung biology/pathobiology with one of the program faculty. Summer training includes a required seminar series. Our training program benefits from the research and mentoring expertise of 25 well-funded, highly collaborative and nationally-recognized faculty from five departments in the College of Medicine, all affiliated with the Center for Lung Biology. Our goal is to provide a vibrant training environment that prepares trainees for subsequent careers in academic, industry and/or government biomedical research venues.

描述（由申请人提供）：本续签申请要求继续支持南阿拉巴马大学医学院肺生物学中心的“细胞信号传导和肺病理学”博士前/短期培训项目。随着我们培训计划的博士前部分在第一个资助周期（2004-2009）中逐渐成熟，我们在第二个资助周期（2009-2014）中增加了短期培训，以支持夏季研究经验。鉴于我们在培训方面取得的成功，在此续签申请中，我们请求继续为短期暑期研究的博士前实习生（6 个名额）和医学生实习生（4 个名额）提供支持。培训研究领域包括肺动脉高压中肺血管收缩和血管重塑的机制、血管和气道平滑肌生物学、肺内皮屏障功能的调节、急性肺损伤、氧化应激中的线粒体功能和信号传导以及气道上皮离子通道的参与和血管内皮功能。我们的项目仍然是美国南部仅有的三个提供肺部研究博士前培训的项目之一，将由 Drs. 共同指导。玛丽·汤斯利（Mary Townsley）和特洛伊·史蒂文斯（Troy Stevens）与内部咨询委员会协商并由杰出的外部顾问进行年度审查。培训计划的总体结构基于 NIH 和其他国家科学领导小组对广泛的跨学科培训的高度重视。我们的博士前培训计划的基础设施由基础医学博士的跨学科核心课程提供。程序。博士前培训生将获得T32 2-3年的支持。这些学员致力于肺生物学方向，从项目教师中寻找导师，并完成信号、生物统计学/实验设计和肺生物学/病理学方面严格的教学高级课程。除了正式的学术课程外，博士前培训生还将参加研讨会和正在进行的研究期刊俱乐部，以及由肺生物学中心组织的杰出职业生存技能培训。短期学员参加长期组织良好的医学生夏季研究项目。这些学员将与一名项目教员一起完成为期 10 周的研究项目，重点关注肺生物学/病理学。暑期培训包括必需的研讨会系列。我们的培训计划受益于来自医学院五个系的 25 名资金雄厚、高度协作且全国认可的教师的研究和指导专业知识，这些教师均隶属于 肺生物学中心。我们的目标是提供一个充满活力的培训环境，为学员在学术、工业和/或政府生物医学研究场所的后续职业做好准备。