MALDI TOF TOF mass spectrometer

MALDI TOF TOF 质谱仪

• 批准号: 6877629
• 负责人: PETER LOBEL
• 金额: $ 50万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6877629
• 关键词: biomedical equipment; biomedical equipment purchase; mass spectrometry; matrix assisted laser desorption ionization; biomedical equipment; biomedical equipment purchase; mass spectrometry; matrix assisted laser desorption ionization

DESCRIPTION (provided by applicant): The application of mass spectrometry to the study of biological molecules has revolutionized many aspects of biomedical research. A group of thirty NIH-supported research groups located at UMDNJ-Robert Wood Johnson Medical School and Rutgers, the State University of New Jersey (Piscataway/New Brunswick Campus) are requesting an Applied Biosystems 4700 Proteomics Analyzer MALDI TOF TOF mass spectrometer to replace and upgrade our existing shared MALDI-TOF mass spectrometry resource. The user group members propose to use this instrument to perform biomedically relevant proteomics studies, protein identification, quality control of recombinant proteins, peptides, and bioconjugates, characterization of post-translational and chemical modifications, cross-linking analysis, deuterium exchange, as well as physical and structural biology studies. Most members of the User Group currently employ mass spectrometry as an integral part of their research and require continued access to a MALDI mass spectrometer, and would benefit immensely from the increased capabilities of the requested instrument. This would result in significant increases in productivity. More importantly, this resource will allow the investigators to expand their research in new directions, and to begin new projects that could not have previously been undertaken.

描述（由申请人提供）：质谱在生物分子研究中的应用已彻底改变了生物医学研究的许多方面。位于新泽西州立大学（Piscataway/New Brunswick Campus）的Umdnj-Robert Wood Johnson医学院和Rutgers的三十个由NIH支持的研究小组要求使用Applied Biosystems 4700蛋白质组织分析仪MALDI TOF TOF MALDI TOF MALDI质量光谱仪，以替换现有的Maldi-Maldi-spectracry spectrigention。用户组成员建议使用该仪器进行生物医学相关的蛋白质组学研究，蛋白质识别，重组蛋白质的质量控制，肽和生物缀合物，翻译后和化学修饰的表征，交叉链接分析，氘交换以及物理生物学研究。该用户组的大多数成员目前都采用质谱作为其研究的组成部分，并需要继续使用MALDI质谱仪，并将受益于所请求的仪器的能力提高。这将导致生产率显着提高。更重要的是，该资源将使研究人员能够在新的方向上扩展研究，并开始以前无法进行的新项目。