Sex Hormones, Related Polymorphisms & Cognitive Decline

性激素，相关多态性

基本信息

批准号：
7118574
负责人：
Kristine Yaffe
金额：
$ 26.93万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-30 至 2009-08-31
项目状态：
已结题

项目摘要

DESCRIPTION: (provided by applicant) The goal of this project is to determine the contributions of sex hormone levels and sex hormone-related gene variants (polymorphisms) to cognitive decline in older men and women and to compare this contribution among black and white elders. Over 33 percent of women and 20 percent of men aged 65 and older will develop dementia during their lifetime and many more will develop a milder form of cognitive impairment. Sex hormones, primarily estradiol and testosterone, may play an important role in maintenance of cognitive health. People who have low concentrations of these hormones may have more rapid cognitive decline than those with high levels. We propose to test this hypothesis by measuring serum levels of estradiol and testosterone and 4-year changes in levels in an ongoing prospective study of 3075 elderly black and white women and men. We will also determine whether physiologically-defined candidate genetic polymorphisms involved in sex hormone metabolism and hormone receptor function are associated with cognitive decline and may play an important role in maintaining cognitive function. As little is known about sex hormones and cognition in older black men and women, we will also determine if associations are similar for black and white elders. Our aims will be addressed as part of the 7- year NIH-funded Health, Aging and Body Composition (Health ABC) Study, currently finishing Year 5. The careful measurement of cognitive e function on multiple domains over 7 years, as well as having stored serum and extracted DNA, will allow for a very efficient approach to answering these questions. Further knowledge of the association between sex hormones, hormone-related polymorphisms and cognitive decline may facilitate preventative strategies to maintain independence and to promote optimum brain aging.

描述：（由申请人提供）该项目的目标是确定性激素水平和性激素相关基因变异（多态性）对老年男性和女性认知能力下降的影响，并比较黑人和白人老年人的这种影响。超过 33% 的 65 岁及以上女性和 20% 的男性会在一生中患上痴呆症，更多人会患上较轻微的认知障碍。性激素，主要是雌二醇和睾酮，可能在维持认知健康方面发挥重要作用。这些激素浓度低的人可能比激素水平高的人认知能力下降得更快。我们建议通过测量雌二醇和睾酮的血清水平以及对 3075 名老年黑人和白人女性和男性进行的一项正在进行的前瞻性研究中水平的 4 年变化来检验这一假设。我们还将确定涉及性激素代谢和激素受体功能的生理学定义的候选基因多态性是否与认知能力下降相关，并可能在维持认知功能中发挥重要作用。由于人们对老年黑人男性和女性的性激素和认知知之甚少，我们还将确定黑人和白人老年人之间的关联是否相似。我们的目标将作为 NIH 资助的为期 7 年的健康、衰老和身体成分 (Health ABC) 研究的一部分得到实现，该研究目前已完成第 5 年。7 年来在多个领域仔细测量认知功能，并储存的血清和提取的 DNA 将提供一种非常有效的方法来回答这些问题。对性激素、激素相关多态性和认知能力下降之间关系的进一步了解可能有助于采取预防策略，以保持独立性并促进最佳的大脑老化。