Mid-life Aging and Urinary Incontinence in a Multi-Ethn*

多民族的中年老龄化和尿失禁*

• 批准号: 7394930
• 负责人: L ELAINE WAETJEN
• 金额: $ 13.88万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-15 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7394930
• 关键词: Address; Affect; African American; Age; Aging; Androgen Receptor; Body Weight Changes; Caucasians; Caucasoid Race; Chinese People; Classification; Condition; Data; Development; Disease regression; Epidemiologic Studies; Estradiol; Estrogens; Ethnic Origin; Ethnic group; Etiology; Follicle Stimulating Hormone; Funding; Genitourinary system; Goals; Hispanics; Hormonal; Hormonal Change; Hormones; Incidence; Incontinence; Inorganic Sulfates; Investigation; Japanese Population; Knowledge; Life Cycle Stages; Longevity; Longitudinal Studies; Measures; Medical; Menopausal Status; Menopause; Mixed Incontinence; Modeling; Outcome; Ovarian; Pathway interactions; Perimenopause; Physiological; Postmenopause; Premenopause; Prevalence; Prevention strategy; Progesterone; Psychosocial Factor; Questionnaires; Race; Range; Regression Analysis; Research Personnel; Resolution; Risk Factors; Role; Serum; Source; Staging; Stress; Symptoms; Testosterone; Time; Unspecified or Sulfate Ion Sulfates; Urinary Incontinence; Woman; Women' s Health; aged; cohort; improved; middle age; modifiable risk; novel; older women; programs; psychologic; racial and ethnic; racial/ethnic difference; social; urinary

Urinary Incontinence is a common, debilitating and costly problem in middle-aged and older women. The prevalence of this condition appears to increase in women between 45-55 years old, an age range that coincides with the menopausal transition. Yet little is known about how the physiological changes associated with mid-life and ovarian aging affect incontinence. This study addresses the first two goals of the NIA RFA Aging through the Lifespan; our interdisciplinary team will examine longitudinally how life- course pathways and differences in risk factors affect urinary incontinence. OBJECTIVE: Our specific aims are: 1) to examine how the incidence and changes in prevalence of incontinence by type (stress, urge, mixed) vary over the stages of the menopausal transition; 2) to identify mid-life physical and psychosocial factors in the development, progression and regression of incontinence by type over 10 years, 3) to explore associations between incontinence and the hormonal changes of the menopausal transition; and 4) to examine the role of race/ethnicity in these specific aims. METHODS: The Study of Women's Health Across the Nation (SWAN) is a longitudinal cohort of 3300 Caucasian, African-American, Chinese, Japanese and Hispanic women who are being followed to characterize the menopausal transition. Our study proposes to use 10 years of questionnaire data with physical and hormonal measures in SWAN to investigate the development and determinants of change in incontinence symptoms across the menopausal transition and into the postmenopausal period. This proposal will primarily involve multivariable regression analysis of ordinal outcomes with mixed models in which random effects are used to model the unmeasured systematic subject-specific sources of variability. RATIONALE: Longitudinal studies that investigate causal sequences and factors associated with the development, progression and regression of incontinence are now needed to improve knowledge about the etiology of incontinence as women age. This investigation will provide this important and novel information that would be otherwise difficult to obtain. With this information we hope to help clinicians advise and treat incontinent mid-life and aging women and to inform incontinence prevention strategies by identifying modifiable risk factors for incontinence and factors associated with improving incontinence.

在中年和老年妇女中，尿失禁是一个普遍，令人衰弱且昂贵的问题。这 这种情况的患病率在45-55岁之间的女性中似乎增加了，这是一个年龄范围 与更年期过渡一致。然而，关于生理如何变化知之甚少 与中年和卵巢衰老有关影响尿失禁。这项研究解决了前两个目标 Nia RFA在整个生命周期中衰老；我们的跨学科团队将纵向研究生活 - 课程途径和危险因素的差异会影响尿失禁。 目的：我们的具体目的是：1）检查发生率的发生率和变化 在更年期过渡的阶段，按类型（压力，敦促，混合）的尿失禁变化； 2）识别 中期生命的身体和心理社会因素在开发，进步和消退的尿失禁过程中 输入10年，3）探索尿失禁与荷尔蒙变化之间的关联 更年期过渡； 4）检查种族/种族在这些特定目标中的作用。 方法：全国妇女健康的研究（天鹅）是3300的纵向队列 被追随 描述了更年期的过渡。我们的研究建议将10年的问卷数据与 天鹅的物理和荷尔蒙措施调查变化的发展和决定因素 整个绝经期和绝经后时期的尿失禁症状。这 提案将主要涉及与混合模型混合模型的多变量回归分析 哪些随机效应用于对未测量的系统特定主体特异性变异来源进行建模。 理由：研究与该因果序列和因素相关的因素的纵向研究 现在需要开发，进步和失禁的进展和回归来改善有关该知识的知识 尿失禁的病因作为妇女年龄。这项调查将提供这一重要而新颖的信息 否则这将很难获得。有了这些信息，我们希望帮助临床医生建议和治疗 失禁中年和老龄妇女，并通过识别来告知预防失禁策略 尿失禁的可修改风险因素和与动力尿失禁有关的因素。