Mid-life Aging & Urinary Incontinence in a Multi-Ethnic

中年老龄化

• 批准号: 7008664
• 负责人: L ELAINE WAETJEN
• 金额: $ 14.42万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-15 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7008664
• 关键词: aging; blood chemistry; clinical research; epidemiology; female; hormone regulation /control mechanism; human data; human middle age (35-64); longitudinal human study; menopause; racial /ethnic difference; sex hormones; urinary incontinence; women' s health

DESCRIPTION (provided by applicant): Urinary Incontinence is a common, debilitating and costly problem in middle-aged and older women. The prevalence of this condition appears to increase in women between 45-55 years old, an age range that coincides with the menopausal transition. Yet little is known about how the physiological changes associated with mid-life and ovarian aging affect incontinence. This study addresses the first two goals of the NIA RFA Aging through the Lifespan; our interdisciplinary team will examine longitudinally how life- course pathways and differences in risk factors affect urinary incontinence. OBJECTIVE: Our specific aims are: 1) to examine how the incidence and changes in prevalence of incontinence by type (stress, urge, mixed) vary over the stages of the menopausal transition; 2) to identify mid-life physical and psychosocial factors in the development, progression and regression of incontinence by type over 10 years, 3) to explore associations between incontinence and the hormonal changes of the menopausal transition; and 4) to examine the role of race/ethnicity in these specific aims. METHODS: The Study of Women's Health Across the Nation (SWAN) is a longitudinal cohort of 3300 Caucasian, African-American, Chinese, Japanese and Hispanic women who are being followed to characterize the menopausal transition. Our study proposes to use 10 years of questionnaire data with physical and hormonal measures in SWAN to investigate the development and determinants of change in incontinence symptoms across the menopausal transition and into the postmenopausal period. This proposal will primarily involve multivariable regression analysis of ordinal outcomes with mixed models in which random effects are used to model the unmeasured systematic subject-specific sources of variability. RATIONALE: Longitudinal studies that investigate causal sequences and factors associated with the development, progression and regression of incontinence are now needed to improve knowledge about the etiology of incontinence as women age. This investigation will provide this important and novel information that would be otherwise difficult to obtain. With this information we hope to help clinicians advise and treat incontinent mid-life and aging women and to inform incontinence prevention strategies by identifying modifiable risk factors for incontinence and factors associated with improving incontinence.

描述（由申请人提供）：中年和老年妇女的尿失禁是一个常见，令人衰弱且昂贵的问题。在45-55岁之间的女性中，这种疾病的患病率似乎增加了，这是一个年龄范围与绝经过渡相吻合的年龄范围。然而，对于与中年和卵巢衰老相关的生理变化如何影响尿失禁。这项研究探讨了NIA RFA衰老的前两个目标。我们的跨学科团队将纵向研究危险因素的生活路线和差异如何影响尿失禁。目的：我们的具体目的是：1）检查逐型尿失禁的发生率和变化在更年期过渡的阶段（压力，敦促，混合）如何变化； 2）确定在10年内挥闭尿失禁的发展，进展和回归中的中期身体和社会心理因素，3）探索尿失禁与绝经过渡的激素变化之间的关联； 4）检查种族/种族在这些特定目标中的作用。方法：全国妇女健康（天鹅）的研究是由3300名高加索人，非裔美国人，中国，日本和西班牙裔妇女组成的纵向队列，这些妇女被遵循，以表征更年期的过渡。我们的研究建议使用SWAN的物理和激素措施使用10年的问卷数据，以研究整个绝经过渡和绝经后时期尿失禁症状变化的发展和决定因素。该建议将主要涉及与混合模型的序数结果的多变量回归分析，其中使用随机效应来对未衡量的系统特定于特定于特定的可变性来源进行建模。基本原理：现在需要研究与尿失禁的发展，进展和消退相关的因果序列和因素，以改善对妇女年龄的尿失禁的知识。这项调查将提供这种重要而新颖的信息，原本很难获得。有了这些信息，我们希望帮助临床医生通过确定可修改的危险因素的尿失禁和与改善尿失禁相关的因素来帮助临床医生建议和治疗失禁妇女的失禁策略。