Development of Multisensory Cortex: Role of Experience

多感觉皮层的发展：经验的作用

• 批准号: 7086769
• 负责人: MARK Thomas WALLACE
• 金额: $ 22.1万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7086769
• 关键词: auditory stimulus; behavior test; cats; controlled environment; developmental neurobiology; early experience; mature animal; neural information processing; neurons; newborn animals; perception; psychobiology; sensory cortex; single cell analysis; superior colliculus; visual deprivation; visual stimulus

DESCRIPTION: (provided by applicant): Perception has long been known to reflect the brain's ability to pool information from many different senses simultaneously. Therefore, it is surprising to note that comparatively little is known about the neural integration that takes place in the cortical neurons believed to underlie these perceptions, and virtually nothing is known about how their physiological properties are crafted during ontogeny. In the current proposal, we posit that early postnatal experience plays a critical role in determining the nature of these multi-sensory processes and their consequent impact on perception and behavior. These postulates will be examined here using neurons in the anterior ectosylvian sulcus (AES) and AES-mediated detection/identification and localization behaviors as models. The AES was targeted because of its high incidence of multi-sensory neurons, the prior demonstration that these neurons can integrate cross-modal information, and the involvement of this area in perception/behavior. In the first phase of this project we will examine the normal chronology with which somatosensory, auditory, visual and multi-sensory AES neurons develop, as well as the maturation of their ability to integrate cross-modal information. In the second phase of the project, we will utilize a multidisciplinary approach to examine what appears to be the most parsimonious hypothesis regarding the necessary and sufficient experiential antecedents of this fundamental information-processing capability: specifically, repeated experience with temporally coincident cross-modal (e.g., visual-auditory) cues. The proposed experiments will also examine whether these visual-auditory experiences must be obtained during early postnatal stages, or whether cross-modal experiences are capable of defining and modifying these neural processes throughout life.

描述：（由申请人提供）：长期以来，人们已经知道感知可以反映大脑同时从许多不同感觉中汇集信息的能力。因此，令人惊讶的是，人们对被认为是这些看法的基础的皮质神经元中发生的神经整合知之甚少，几乎对它们的生理特性在个体中如何制作而言一无所知。在当前的提案中，我们认为早期产后经验在确定这些多感觉过程的性质及其对感知和行为的影响方面起着关键作用。这些假设将在这里使用神经元（AES）（AES）和AES介导的检测/鉴定和定位行为作为模型进行检查。 AE的靶向是由于其多感觉神经元的高发病率，因此这些神经元可以整合跨模式信息的先前证明，以及该区域参与感知/行为。在该项目的第一阶段中，我们将研究平衡，听觉，视觉和多感应AES神经元的正常年表，以及它们整合跨模式信息的能力的成熟。在项目的第二阶段中，我们将利用一种多学科方法来研究这种基本信息处理能力的必要和足够的经验前提的最简约的假设：具体，具有临时偶然的交叉模式（例如，视觉审核）的重复经验。拟议的实验还将检查是否必须在产后早期阶段获得这些视觉审计经验，或者是否能够在一生中定义和修改这些神经过程。