CEREBRAL ORGANIZATION FOLLOWING COCHLEAR IMPLANT

人工耳蜗植入后的大脑组织

• 批准号: 6650920
• 负责人: STEPHEN G LOMBER
• 金额: $ 7.48万
• 依托单位: UNIVERSITY OF TEXAS DALLAS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6650920
• 关键词: animal communication behavior; auditory cortex; auditory stimulus; behavior test; cats; cochlear implants; congenital deafness; electrostimulus; form /pattern perception; hearing; hearing tests; neurophysiology; neuropsychology; sound perception; space perception; vision tests; visual perception; visual stimulus

DESCRIPTION (provided by applicant): Following implantation of a cochlear prosthetic, auditory cortex exhibits a remarkable plasticity in its ability to establish auditory signal processing after a period of deprivation. Our long-term goal is to understand and define the capabilities of non-primary auditory cortex to establish auditory function following cochlear implant. This endeavor requires the elucidation of the essential contributions that non-primary auditory cortex makes to fundamental aurally-guided behaviors in the intact (hearing) condition, as well as an assessment of the behavioral capabilities of non-primary auditory cortex following cochlear implant in congenitally deaf subjects. The first specific aim of this application is to determine that non-primary auditory cortex contains specialized regions for the processing of pattern perception and spatial localization. In intact cats, we will examine the contributions that the anterior and posterior auditory fields (AAF and PAF, respectively) make to pattern recognition and the perception of auditory space. Each area will be reversibly deactivated with cooling and we expect to be able to doubly-dissociate pattern discrimination and spatial localization functions to AAF and PAF cortices, respectively. The second aim in the study is to determine if congenitally deaf (CD) cats with cochlear prosthetics implanted early in development (2 months of age) can establish aurally-mediated behaviors. We will test if the animals are able to attain high performance levels on the auditory discrimination, detection, and localization tasks examined in Aim 1. The results of the first two aims are brought together in Aim 3, where we will combine the CD cats with cochlear implants examined in Aim 2 with the reversible deactivation techniques used in Aim 1 to determine if the characteristic normal functional cartography of non-primary auditory cortex is established following early cochlear implantation. To accomplish this, we will reversibly deactivate AAF and PAF cortices in the CD cats with cochlear implants while performing the battery of auditory tasks described above, and compare the results with those from the intact cats in Aim 1. The results from these studies will be directly applicable to clinical situations concerning the functional outcomes of cochlear implants in young children.

描述（由申请人提供）：在植入人工耳蜗假体后，听觉皮层在剥夺一段时间后建立听觉信号处理的能力表现出显着的可塑性。我们的长期目标是了解和定义非主要听觉皮层在人工耳蜗植入后建立听觉功能的能力。这项努力要求阐明非主要听觉皮层对完整（听力）条件下基本的听觉指导行为做出的基本贡献，以及评估非原子型植入术后非基本听觉皮层的行为能力。该应用程序的第一个具体目的是确定非主要听觉皮层包含用于处理模式感知和空间定位的专业区域。在完整的猫中，我们将研究前和后听觉场（分别AAF和PAF）对模式识别和听觉空间的感知所做的贡献。每个区域将通过冷却来可逆地停用，我们希望能够分别对AAF和PAF Cortices分别划分分离模式歧视和空间定位功能。该研究的第二个目的是确定先天性聋（CD）猫在发育早期（2个月大）早期植入的人工耳蜗的猫（CD）猫是否可以建立倾斜介导的行为。我们将测试动物是否能够在AIM 1中检查的听觉歧视，检测和本地化任务上达到高性能水平。前两个目标的结果将AIM 3中的结果汇总在一起，在AIM 3中，我们将在AIM 2中检查的CD猫与AIM 2中检查的同性恋植入物与AIM 2中使用的AIM 1中使用，以确定特征性的正常功能性的功能性，以确定特征性的正常功能，以确定特征性的功能性，该功能是符合特征性的功能。植入。为此，我们将在执行上述听觉任务的同时将AAF和PAF皮层倒入CD猫中的AAF和PAF皮质，并将其与AIM 1中完整猫的结果进行比较。这些研究的结果将直接适用于与年轻儿童相关的临床情况。