Rehabilitation of Neural Spatial Neglect

神经空间忽视的康复

• 批准号: 6681596
• 负责人: BERTRAM R PAYNE
• 金额: $ 54.13万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6681596
• 关键词: auditory stimulus; behavior test; brain disorders; brain injury; cats; disease /disorder model; experimental brain lesion; ibotenate; nervous system disorder therapy; neural information processing; neuroanatomy; nonhuman therapy evaluation; sound perception; technology /technique development; transcranial magnetic stimulation; visual perception; visual stimulus; auditory stimulus; behavior test; brain disorders; brain injury; cats; disease /disorder model; experimental brain lesion; ibotenate; nervous system disorder therapy; neural information processing; neuroanatomy; nonhuman therapy evaluation; sound perception; technology /technique development; transcranial magnetic stimulation; visual perception; visual stimulus

DESCRIPTION (provided by applicant): Our long-term aim is to rehabilitate neural spatial neglect. Unilateral neglect is a complex neurological disorder induced by unilateral brain damage that is characterized by lack of conscious perception, awareness, attention, and cognition of objects in the space contralateral to the brain damage. In a cat model of spatial neglect, unilateral deactivation of posterior and inferior parietal cortex induces a profound neglect of objects in the contralateral hemifield. Paradoxically, the neglect is reversed by additional deactivation of the homotopic region in the contralateral hemisphere. This model system offers the opportunity to investigate the neural mechanisms which, when damaged, produce neglect, and to develop an effective therapeutic strategy to reverse neglect in humans. The Specific Aims of the proposed work are to test three hypotheses on: 1) the use of repetitive transcranial magnetic stimulation (rTMS) to reverse neglect in a cat model, 2) to learn more about the primary & secondary functional impacts of lesions and stimulations on the attention network, & 3) interactions of lesions & rTMS on distant structures as the impact of the lesion emerges & when it is stable. The knowledge gained will aid the development of therapeutic and interventional strategies for application to human patients suffering from neglect. Animal studies provide the best possibility of studying the neglect syndrome, and its paradoxical reversal, in a highly systematic way and with considerable anatomical rigor. Our model of spatial neglect will allow systematic identification and dissection of pathways affected by the lesion, provide insights into the brain mechanisms underlying the reversal of neglect, lead to the development of therapeutic strategies to rehabilitate and ultimately reverse neurological neglect in human patients. Our over riding goal is to minimize rTMS parameters yet provide maximum therapeutic duration. It is a realistic goal that can be achieved with the proposed whole-animal behavioral assays and supplemented by the brain-wide network analyses on the functional impacts and interactions of parietal lesions and applied TMS on neurons. The data are of obvious translational importance for neurorehabilitation of neglect and may have wider-ranging impact on other neurologic and psychiatric diseases.

描述（由申请人提供）：我们的长期目的是修复神经空间忽视。单方面忽视是一种复杂的神经系统疾病，该神经系统疾病是由单侧脑损伤引起的，其特征是缺乏有意识的知觉，意识，注意力和对物体与脑损伤相对的物体的认知。在空间忽视的CAT模型中，后壁皮层和下壁皮层的单方面停用会引起对侧半菲尔德中对物体的深刻忽视。矛盾的是，忽视会因对侧半球的同位区域的额外停用而逆转。该模型系统提供了调查神经机制的机会，这些神经机制在损坏后会忽视，并制定有效的治疗策略来逆转人类的忽视。 The Specific Aims of the proposed work are to test three hypotheses on: 1) the use of repetitive transcranial magnetic stimulation (rTMS) to reverse neglect in a cat model, 2) to learn more about the primary & secondary functional impacts of lesions and stimulations on the attention network, & 3) interactions of lesions & rTMS on distant structures as the impact of the lesion emerges & when it is stable.获得的知识将有助于发展治疗和介入策略，以应用于患有忽视的人类患者。 动物研究提供了研究疏忽综合征及其自相矛盾的逆转的最佳可能性，并以高度系统的方式进行了严格的严格性。我们的空间忽视模型将允许对受病变影响的途径进行系统的识别和解剖，提供对忽视逆转的脑机制的见解，从而发展出治疗策略以康复，并最终逆转人类患者的神经疏忽。 我们过度的骑行目标是最大程度地减少RTMS参数，但提供最大的治疗持续时间。这是一个现实的目标，可以通过提出的全动物行为分析来实现，并通过对顶叶病变的功能影响和相互作用和对神经元应用的TMS的功能影响和相互作用进行补充。这些数据对于忽视神经居住而显而易见的转化重要性，可能对其他神经系统和精神病疾病产生更大的影响。