COGNITION AFTER LESIONS OF IMMATURE CEREBRAL CORTEX

未成熟大脑皮层损伤后的认知

• 批准号: 6639476
• 负责人: BERTRAM R PAYNE
• 金额: $ 40.75万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-19 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6639476
• 关键词: age difference; autoradiography; behavior; behavioral /social science research tag; brain injury; brain mapping; cats; cerebral cortex; cognition; developmental neurobiology; electrophysiology; experimental brain lesion; histology; immature animal; light microscopy; memory; neural information processing; neuroanatomy; neurogenesis; neuropsychological tests; neuropsychology; radiotracer; visual perception

DESCRIPTION (Provided by applicant): Brain lesions incurred early in life produce a different brain from that reached after normal development. The lesion-induced modifications are specific & ordered and they contribute to sparing of cognitive processes that are severely handicapped by equivalent lesions incurred by the mature brain. The long-term goal is to identify classes of spared functions and the structures contributing to them. The specific aim of the proposed work is to test the two component hypothesis that: 1) cognitive functions are spared by early lesions of areas 17 & 18, & 2) the contributions to cognition made by middle suprasylvian (MS) cortex, in the parietal region, and by ventral posterior suprasylvian (vPS) cortex, in the temporal region, differ from contributions the same regions make to cognition & behavior in the intact brain. Normally these two regions make clearly discriminable, and non-overlapping, contributions to cognition of space & action, and to learning, memory & recognition of forms. Studies will be carried out on mature cats that incurred damage of areas 17 & 18 on P1, P28, and in adulthood (P180), and normative data will be collected from intact cats. After extensive training on a battery of behavioral tasks designed to define the magnitude of the cognitive sparing, cooling loops will be implanted to temporarily deactivate MS or vPS cortices and assess the contributions the two regions make to the spectrum of spared functions. The behavioral tasks will reveal: 1) classes of spared cognitive functions; 2) age dependent differences in sparing; 3) whether remaining MS & vPS regions adopt functions normally associated with areas 17 & 18; & 4) whether functions normally localized to either MS or vPS cortices become dispersed, as substantial rewirings suggest. The work will provide detailed information on the capacities of the immature cerebral cortex to compensate for cognitive functions severely handicapped following equivalent damage of the mature cerebrum. The identification of these capacities is important for comprehending the spectrum of consequences of early cerebral cortical damage, and for developing therapeutic strategies that attempt to enhance the sparing of cognitive functions.

描述（申请人提供）：生命早期发生的脑病变 正常发育后产生与达到的大脑不同的大脑。这 病变引起的修饰是特定和有序的，它们有助于 保留严重残障的认知过程 成熟大脑引起的病变。长期目标是确定课程 不幸的功能及其对它们的贡献的结构。具体目标 拟议的工作是测试两个组成假设：1）认知 17＆18和2）贡献的区域的早期病变幸免于此 在顶部区域的上prasylvian（MS）皮质的认知，位于顶部地区 并由腹侧后腹（VPS）皮质，在时间区域 与相同地区对认知和行为相同的贡献有所不同 完整的大脑。通常，这两个区域明显可以区分，并且 不重叠，对空间和行动的认知以及学习的贡献， 记忆和表格的识别。研究将对成熟的猫进行 在P1，P28和成年（P180）上造成了17和18的区域损坏，以及 规范性数据将从完整的猫中收集。经过广泛的培训 旨在定义认知幅度的一系列行为任务 保证，冷却环将被植入以暂时停用MS或VP 皮层并评估两个区域对光谱的贡献 保留功能。行为任务将揭示：1）遗憾的类 认知功能； 2）年龄依赖性差异； 3）是否 剩余的MS＆VP区域采用通常与区域17＆ 18; ＆4）是否正常位于MS或VPS Cortices的功能 正如重大的重新布局所暗示的那样，变得分散。工作将提供 关于未成熟大脑皮质能力的详细信息 在等效后严重残障地补偿认知功能 成熟大脑的损害。这些能力的识别是 理解早期大脑后果的范围很重要 皮质损害，以及制定试图尝试的治疗策略 增强认知功能的保证。