A Multisensory Framework for Developmental Dyslexia

发展性阅读障碍的多感官框架

• 批准号: 7176387
• 负责人: MARK Thomas WALLACE
• 金额: $ 3.84万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7176387
• 关键词: auditory stimulus; behavioral /social science research tag; clinical research; dyslexia; functional magnetic resonance imaging; human subject; language; neural information processing; psychophysics; psychophysiology; reading; temporal lobe /cortex; visual stimulus

DESCRIPTION (provided by applicant): Although there is growing evidence that developmental dyslexia is characterized by problems in basic sensory processes, there has been little work examining how information processing between the different sensory modalities is affected in this disorder. This is despite the fact that the development of reading and linguistic skills is an inherently cross-modal process, involving the integration of the visual and auditory components of the language representation. Based on the previous literature and our preliminary data, it is our hypothesis that dyslexics will indeed show a disorder in multisensory processing, which will manifest as an abnormally large window of time within which visual and auditory stimuli are bound into a unified percept. To test this hypothesis, and to examine the brain substrates that underlie these altered multisensory processes, we propose to conduct psychophysical and fMRI experiments. These experiments will use a multisensory temporal order judgment task in order to delineate the temporal window of multisensory integration in both dyslexic and normal reading subjects, as well as examining the differential patterns of brain activation in multisensory cortical regions during task performance. Together, the results of this study will serve to further our understanding of the neurophysiological bases of dyslexia.

描述（由申请人提供）：尽管有越来越多的证据表明发育阅读障碍的特征是基本感觉过程中的问题，但很少有工作研究这种疾病中不同感觉方式之间的信息处理如何受到影响。尽管事实是，阅读和语言技能的发展是一个固有的跨模式过程，涉及语言表示的视觉和听觉组成部分的整合。基于以前的文献和我们的初步数据，我们的假设是，诵读困难确实会显示多感官处理中的障碍，这将表现为异常较大的时间窗口，在该时间窗口中，视觉和听觉刺激被束缚在统一的感知中。为了检验这一假设，并检查了这些改变的多感官过程的脑底物，我们建议进行心理物理和fMRI实验。这些实验将使用多感官的时间顺序判断任务，以描述内乐和正常阅读主题中多感官整合的时间窗口，并检查任务性能期间多质皮质区域中脑激活的差异模式。总之，这项研究的结果将有助于我们对阅读障碍的神经生理基础的理解。