Brainstem timing and reading disability

脑干计时和阅读障碍

• 批准号: 7114160
• 负责人: KAREN BANAI
• 金额: $ 4.6万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114160
• 关键词: auditory cortex; auditory discrimination; auditory pathways; auditory stimulus; behavior test; behavioral /social science research tag; behavioral medicine; brain stem; child (0-11); clinical research; evoked potentials; hearing tests; human subject; human therapy evaluation; learning disorders; neural information processing; neuropathology; neuropsychological tests; patient oriented research; performance; phonology; postdoctoral investigator; psychometrics; reading; reading disorder; speech recognition; training

DESCRIPTION (provided by applicant): Our long term goal is to develop an effective training regime for auditory-based learning disabilities. The goal of the proposed study is to further understand the role of brainstem timing in auditory processing and literacy. Specifically, we are interested in the functional relations between brainstem and cortical processing, auditory processing and literacy in children with reading disability. We will characterize the auditory processing profile of children with reading disability and abnormal brainstem timing. Consequently, a perceptual training paradigm will be used to test the hypothesis that brainstem timing can be improved. We will also test the hypothesis that such training will generalize to speech perception and literacy related skills. Auditory evoked potentials and behavioral performance will be measured before and after behavioral training and compared between reading disabled children with normal and abnormal brainstem timing and normal learning children. We expect that training will result in changes in both cortical and brainstem function as well as in behavioral measures relating to brainstem timing. This study will thus result in better understanding of the physiological basis of learning disability and of the organization of the auditory system.

描述（由申请人提供）：我们的长期目标是为基于听觉的学习障碍制定有效的培训制度。拟议的研究的目的是进一步了解脑干时间在听觉处理和识字中的作用。具体而言，我们对阅读障碍儿童的脑干与皮质处理，听觉处理和识字率之间的功能关系感兴趣。我们将表征阅读障碍和脑干异常时间的儿童的听觉处理概况。因此，将使用感知训练范式来测试可以改善脑干时间的假设。我们还将检验以下假设：这种培训将推广到语音感知和与识字相关的技能。在行为训练之前和之后，将衡量听觉诱发的潜力和行为表现，并比较读书的残疾儿童正常和异常的脑干时间和正常学习的孩子。我们预计培训将导致皮质和脑干功能以及与脑干时间有关的行为度量的变化。因此，这项研究将更好地了解学习障碍的生理基础和听觉系统的组织。