Brainstem timing and reading disability

脑干计时和阅读障碍

• 批准号: 7168012
• 负责人: KAREN BANAI
• 金额: $ 4.88万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7168012
• 关键词: Acoustics; Affect; Auditory; Auditory Evoked Potentials; Auditory system; Behavioral; Biological; Brain; Brain Stem; Child; Complex; Condition; Detection; Development; Diagnosis; Disabled Children; Discrimination; Goals; Individual; Learning; Learning Disabilities; Measures; Performance; Physiological; Procedures; Process; Reader; Reading; Reading Disabilities; Role; Signal Transduction; Speech Discrimination; Speech Perception; Speech Sound; Structure; Testing; Time; Training; Treatment Protocols; Work; auditory pathway; base; behavior measurement; biological research; design; improved; interest; literacy; phonology; remediation; response; skills; sound

DESCRIPTION (provided by applicant): Our long term goal is to develop an effective training regime for auditory-based learning disabilities. The goal of the proposed study is to further understand the role of brainstem timing in auditory processing and literacy. Specifically, we are interested in the functional relations between brainstem and cortical processing, auditory processing and literacy in children with reading disability. We will characterize the auditory processing profile of children with reading disability and abnormal brainstem timing. Consequently, a perceptual training paradigm will be used to test the hypothesis that brainstem timing can be improved. We will also test the hypothesis that such training will generalize to speech perception and literacy related skills. Auditory evoked potentials and behavioral performance will be measured before and after behavioral training and compared between reading disabled children with normal and abnormal brainstem timing and normal learning children. We expect that training will result in changes in both cortical and brainstem function as well as in behavioral measures relating to brainstem timing. This study will thus result in better understanding of the physiological basis of learning disability and of the organization of the auditory system.

描述（由申请人提供）：我们的长期目标是为听觉学习障碍制定有效的培训制度。拟议研究的目标是进一步了解脑干计时在听觉处理和读写能力中的作用。具体来说，我们对阅读障碍儿童的脑干和皮质处理、听觉处理和读写能力之间的功能关系感兴趣。我们将描述有阅读障碍和脑干时序异常的儿童的听觉处理特征。因此，感知训练范式将用于测试脑干时序可以改善的假设。我们还将检验这样的假设：此类培训将推广到言语感知和识字相关技能。将在行为训练前后测量听觉诱发电位和行为表现，并将脑干时序正常和异常的阅读障碍儿童与正常学习儿童进行比较。我们预计训练将导致皮质和脑干功能以及与脑干计时相关的行为测量的变化。因此，这项研究将有助于更好地理解学习障碍的生理基础和听觉系统的组织。