Family Imaging Study of Children at Risk for Anxiety

有焦虑风险的儿童的家庭影像研究

• 批准号: 7124210
• 负责人: JERROLD F ROSENBAUM
• 金额: $ 46.74万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-20 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7124210
• 关键词: adolescence (12-20); amygdala; anxiety disorders; bioimaging /biomedical imaging; brain mapping; clinical research; disease /disorder proneness /risk; emotions; family structure /dynamics; frontal lobe /cortex; functional magnetic resonance imaging; human subject; major depression; mental health epidemiology; neural information processing; neurophysiology; panic disorder; parents; personality

DESCRIPTION (provided by applicant): Family Imaging Study of Children at Risk for Anxiety: The proposed family study will employ functional magnetic resonance imaging (fMRI) methods to investigate the neural substrates of anxiety disorders in parents and their offspring as well as vulnerability factors that confer increased risk to develop anxiety disorders. Via a concurrently funded project, we enjoy access to the unique longitudinally followed Massachusetts General Hospital sample of parents and their adolescent offspring (N=446) at risk for panic disorder (PD), comparison offspring at risk for depression (MD), and children without vulnerability to mood or anxiety disorders. We propose to use established fMRI cognitive behavioral probes to test specific hypotheses regarding differences in amygdalo-frontal function related to behavioral inhibition (Bl) and parental panic disorder as factors that confer risk to develop anxiety disorders in adolescent offspring. In addition, we will investigate pathophysiology by examining differences in amygdalo-frontal function between adolescents with and without anxiety disorders while controlling for Bl and parental diagnosis. Finally, we will test for familial associations in amygdalo-frontal function between parents and their offspring. The proposed research promises to advance knowledge regarding the pathophysiology of anxiety disorders from adolescence to adulthood and to elucidate the neural basis of risk factors for developing anxiety disorders, including behavioral inhibition and parental diagnosis.

描述（由申请人提供）：有焦虑风险的儿童的家庭影像研究：拟议的家庭研究将采用功能磁共振成像（fMRI）方法来研究父母及其后代焦虑症的神经基础以及易受伤害的因素增加患焦虑症的风险。通过一个同时资助的项目，我们可以访问马萨诸塞州总医院独特的纵向跟踪样本，其中包括有惊恐障碍 (PD) 风险的父母及其青少年后代 (N=446)、有抑郁症风险 (MD) 的比较后代以及儿童不易受到情绪或焦虑障碍的影响。我们建议使用已建立的功能磁共振成像认知行为探针来测试与行为抑制（Bl）和父母恐慌症相关的杏仁核额叶功能差异的具体假设，这些差异是导致青少年后代患焦虑症的风险因素。此外，我们将通过检查患有和不患有焦虑症的青少年之间杏仁核额叶功能的差异来研究病理生理学，同时控制 Bl 和父母的诊断。最后，我们将测试父母与其后代之间杏仁核额叶功能的家族关联。拟议的研究有望增进有关从青春期到成年期焦虑症病理生理学的知识，并阐明发生焦虑症的危险因素的神经基础，包括行为抑制和父母诊断。