PSYCHOPATHOLOGY IN CHILDREN OF AGORAPHOBIC PARENTS

广场恐惧症父母的孩子的心理病理学

• 批准号: 2415946
• 负责人: JERROLD F ROSENBAUM
• 金额: $ 15.35万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-01 至 1998-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2415946
• 关键词: anxiety; anxiety disorders; avoidance behavior; behavior test; behavioral /social science research tag; blood pressure; child behavior; disease /disorder proneness /risk; environmental stressor; family structure /dynamics; heart rate; human subject; labor complications; mental disorder diagnosis; panic disorder; parents; preschool child (1-5); psychophysiology; socioeconomics; thermography

This proposal tests the hypothesis that Behavioral Inhibition is an expression of a constitutional predisposition to anxiety disorders in children at-risk for anxiety disorders and is predictive of subsequent anxiety disorders in children. The study includes initial assessments of "behavioral inhibition to the unfamiliar" (Behavioral Inhibition) in 225 children ages 4.0 to 5.9 years, and a follow-up assessment of Behavioral Inhibition and emergent psychopathology two years later. We will sample young offspring of parents with panic disorder and agoraphobia (N=150) and parents having no psychiatric illness (normal comparison children) (N=75). The current proposal would be the beginning of a long term project aimed at assessing the ability of Behavioral Inhibition, assessed at an early age, to serve as a predictor of anxiety disorders in childhood, adolescence and adulthood. Behavioral Inhibition, as described by Kagan and colleagues, is the consistent tendency to display fear and withdrawal in situations that are novel or unfamiliar. Since these responses, which are measured in a laboratory setting, are assumed to reflect low thresholds of limbic arousal to challenge, they may underlie a risk for the development of anxiety disorder. This project is a proposed investigation of Behavioral Inhibition, and in particular, Behavioral Inhibition persisting at follow-up assessment (Stable Behavioral Inhibition), as a potential early predictor for the later development of anxiety disorders. The rationale and main impetus for this study stem directly from our group's prior work with children of parents with panic disorder and agoraphobia and children originally identified in infancy as exhibiting Behavioral Inhibition. The pilot work supports the hypotheses to be tested, the estimation of sample size, and the overall feasibility of this project. Since pilot work suggests that Behavioral Inhibition is a manifestation of the constitutional vulnerability to anxiety disorders, we hypothesize that high Ask children (of parents having panic disorder with agoraphobia) will have higher rates of Behavioral Inhibition and Stable Behavioral Inhibition than children of never ill comparison parents. At a two-year follow-up, more anxiety disorders are expected among children who had Behavioral Inhibition at the initial assessment compared with other children, In addition, the project includes exploratory assessments of the role of environmental factors as additional predictors for Behavioral Inhibition or psychopathology. Studies of children at-risk and the identification of factors responsible for childhood psychopathology are considered to be of highest research priority in the Institute of Medicine's Special Committee Report on "Research on Children and Adolescents with Mental, Behavioral, and Developmental Disorders" and in the National Institute of Mental Health National Plan that followed. The proposed work represents the most comprehensive assessment of children at-risk for anxiety disorders yet undertaken. The products of this research, in addition to early identification of children at highest risk for later development of anxiety disorders, could lead to the design of protocols for primary preventive or early intervention programs.

该提案检验了一个假设，即行为抑制是 表达宪法易感性焦虑症 儿童处于焦虑症的风险中，并可以预测随后的 儿童的焦虑症。 该研究包括对 225中的“行为抑制对不熟悉的行为”（行为抑制） 4.0至5.9岁的儿童和行为的随访评估 两年后的抑制和新兴的心理病理学。 我们将采样 父母患有恐慌症和恐惧症的年轻后代（n = 150） 父母没有精神病（正常比较子女） （n = 75）。 当前的提议将是长期的开始 旨在评估行为抑制能力的项目，评估 在很小的时候，作为焦虑症的预测因素 童年，青春期和成年。 正如Kagan及其同事所述的行为抑制是 在情况下表现出恐惧和戒断的一致趋势 新颖或不熟悉。 由于这些响应是在 假定实验室环境反映了边缘的低阈值 引起挑战的挑战，它们可能是发展的风险 焦虑症。 该项目是对行为的拟议调查 抑制，尤其是行为抑制持续存在 后续评估（稳定的行为抑制），作为潜在的早期 预测焦虑症的后来发展。 理由 这项研究的主要动力直接源于我们小组的先前工作 与患有恐慌症和恐惧症的父母的孩子和孩子 最初在婴儿期被鉴定为表现出行为抑制。 飞行员工作支持要测试的假设 样本量以及该项目的总体可行性。 自飞行员以来 工作表明行为抑制是 宪法易受焦虑症的脆弱性，我们假设 高问孩子（父母患有恐惧症的父母） 行为抑制和稳定的行为率将具有更高的速度 抑制比永不生病的父母的孩子。 为期两年 随访，预计有更多焦虑症 初次评估时的行为抑制作用与其他 此外，儿童还包括对 环境因素作为行为的其他预测因素的作用 抑制或心理病理学。 对儿童高危儿童的研究以及负责因素的识别 对于儿童期，心理病理学被认为是最高的研究 医学研究所特别委员会报告的优先事项 ”关于精神，行为和行为和青少年的研究 发展障碍”和国家心理健康研究所 随后的国家计划。 提议的工作最多代表 对焦虑症的儿童的全面评估 进行。 除了早期，这项研究的产品 确定有最高风险的儿童以后发展 焦虑症，可能导致设计主要方案 预防或早期干预计划。