QEEG and qSpike: brain indicator of temperature manipulation after cardiac arrest

QEEG 和 qSpike：心脏骤停后温度控制的大脑指标

• 批准号: 7019816
• 负责人: NITISH VYOMESH THAKOR
• 金额: $ 22.03万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-18 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7019816
• 关键词: brain; brain injury; heart arrest; hyperthermia; hypothermia; temperature

DESCRIPTION (provided by applicant): Recent clinical studies have shown that temperature perturbation either as hypothermia or hyperthermia has a profound effect on brain injury and recovery after cardiac arrest. While the temperature manipulation, either by hypothermia or fever reduction to prevent hyperthermia is widespread in clinical practice, the precise effect of temperature on brain injury is not fully known. Indeed, no methods to directly titrate the efficacy of hypothermia treatment, such as the time to initiate therapy, more optimal range or duration, are available. Effect of temperature manipulation on cortical function is not known either. In our preliminary studies we have observed that the neuroelectrical response, as reflected in the real time neuronal firing and the cortical neural activity, namely electroencephalogram (EEG), is directly affected by temperature. Together these two measurements can provide a real-time assessment of these brain responses from a limited yet specific area (spikes) to bulk or global areas of the brain (EEG). The two aims of this project are (1) to study the neuro- electrical response by quantitative EEG (QEEG) methods serving as a real time, non-invasive, electrical marker of the brain's response to temperature manipulation, and (2) to evaluate the interaction of the subcortical (spike activity) and cortical QEEG responses of the brain to temperature manipulation. Proof of concept obtained through this project will first of all lead to a clinically relevant tool to noninvasively monitor and titrate hypothermic neuroprotection following cardiac arrest. In addition, this feasibility study will open the door to more fundamental research on effects of hypothermia or hyperthermia at neuronal level as well as clinical investigations designed to optimize the therapy in humans.

描述（由申请人提供）：最近的临床研究表明，由于体温过低或高温扰动，温度扰动对脑损伤和心脏骤停后的恢复具有深远的影响。尽管在临床实践中，温度操纵是通过体温过低或减少发烧以防止高温的，但温度对脑损伤的精确影响尚不完全清楚。实际上，没有直接滴定低温治疗功效的方法，例如启动治疗的时间，更佳的范围或持续时间。温度操纵对皮质功能的影响也不为人所知。在我们的初步研究中，我们观察到，在实时神经元放电和皮质神经活性（即脑电图（EEG））中所反映的神经电作者反应直接受温度影响。这两种测量值共同可以对这些大脑反应进行实时评估，从有限但特定的区域（尖峰）到大脑的批量或全球区域（EEG）。该项目的两个目的是（1）通过定量脑电图（QEEG）方法研究神经电反应，该方法是实时的，无创的，无创的，大脑对温度操纵响应的电标，以及（2）评估亚皮层（SPIKE活性）（SPIKE活动）和皮质QEEG的相互作用。通过该项目获得的概念证明将首先导致一种与临床相关的工具，以无创监测和滴定心脏骤停后的低温神经保护作用。此外，这项可行性研究将为对神经元水平的体温过低或高温影响以及旨在优化人类治疗的临床研究开辟更多基础研究。