QEEG and qSpike: brain indicator of temperature manipulation after cardiac arrest

QEEG 和 qSpike：心脏骤停后温度控制的大脑指标

• 批准号: 7229867
• 负责人: NITISH VYOMESH THAKOR
• 金额: $ 18.09万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-18 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7229867
• 关键词: Affect; Area; Brain; Brain Injuries; Cerebral Ischemia; Clinical; Clinical Research; Clinical Trials; Electroencephalogram; Electroencephalography; Feasibility Studies; Fever; Fire - disasters; Frequencies; Heart Arrest; Human; Injury; Invasive; Ischemic Brain Injury; Lead; Measurement; Methods; Monitor; Neurons; Pattern; Range; Recovery; Resuscitation; Signal Transduction; Temperature; Thalamic structure; Time; Visual; clinically relevant; computerized; computerized data processing; concept; design; fundamental research; hyperthermia treatment; natural hypothermia; neuroprotection; novel; prevent; relating to nervous system; response; tool

DESCRIPTION (provided by applicant): Recent clinical studies have shown that temperature perturbation either as hypothermia or hyperthermia has a profound effect on brain injury and recovery after cardiac arrest. While the temperature manipulation, either by hypothermia or fever reduction to prevent hyperthermia is widespread in clinical practice, the precise effect of temperature on brain injury is not fully known. Indeed, no methods to directly titrate the efficacy of hypothermia treatment, such as the time to initiate therapy, more optimal range or duration, are available. Effect of temperature manipulation on cortical function is not known either. In our preliminary studies we have observed that the neuroelectrical response, as reflected in the real time neuronal firing and the cortical neural activity, namely electroencephalogram (EEG), is directly affected by temperature. Together these two measurements can provide a real-time assessment of these brain responses from a limited yet specific area (spikes) to bulk or global areas of the brain (EEG). The two aims of this project are (1) to study the neuro- electrical response by quantitative EEG (QEEG) methods serving as a real time, non-invasive, electrical marker of the brain's response to temperature manipulation, and (2) to evaluate the interaction of the subcortical (spike activity) and cortical QEEG responses of the brain to temperature manipulation. Proof of concept obtained through this project will first of all lead to a clinically relevant tool to noninvasively monitor and titrate hypothermic neuroprotection following cardiac arrest. In addition, this feasibility study will open the door to more fundamental research on effects of hypothermia or hyperthermia at neuronal level as well as clinical investigations designed to optimize the therapy in humans.

描述（由申请人提供）：最近的临床研究表明，温度扰动无论是体温过低还是体温过高，对脑损伤和心脏骤停后的恢复都有深远的影响。虽然通过降低体温或降低体温来防止体温过高的温度控制在临床实践中很普遍，但温度对脑损伤的确切影响尚不完全清楚。事实上，目前还没有直接滴定低温治疗效果的方法，例如开始治疗的时间、更佳的范围或持续时间。温度控制对皮质功能的影响也不清楚。在我们的初步研究中，我们观察到实时神经元放电和皮质神经活动（即脑电图（EEG））所反映的神经电反应直接受到温度的影响。这两种测量结合起来可以实时评估从有限但特定的区域（尖峰）到大脑的整体或全局区域（EEG）的这些大脑反应。该项目的两个目标是（1）通过定量脑电图（QEEG）方法研究神经电反应，作为大脑对温度操纵反应的实时、非侵入性电标记，以及（2）评估大脑皮质下（尖峰活动）和皮质 QEEG 对温度控制反应的相互作用。通过该项目获得的概念验证将首先产生一种临床相关工具，用于无创监测和滴定心脏骤停后的低温神经保护。此外，这项可行性研究将为有关低温或高温对神经元水平影响的更基础研究以及旨在优化人类治疗的临床研究打开大门。