Power Harvesting in Implanted Neural Probes

植入神经探针中的能量收集

基本信息

批准号：
7232464
负责人：
NITISH VYOMESH THAKOR
金额：
$ 21.05万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-05-15 至 2009-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7232464
关键词：
Animal Model Animals Brain Brain Diseases Carbon Cerebral Ischemia Charge Chemicals Chronic Custom Development Electrodes Epilepsy Frequencies Funding Future Glutamates Goals Hand Harvest Heart Arrest Implant Investigation Ischemic Brain Injury Laboratories Link Measurement Measures Medical Technology Microelectrodes Microfabrication Miniaturization Modeling Neurons Oxides Population Radio Research Research Methodology Risk Rodent Model Signal Transduction Silicon Source Staging System Technology Time United States National Institutes of Health Universities Wireless Technology Work awake brain tissue concept design implanted sensor innovation innovative technologies instrument interest microsystems nervous system disorder neurochemistry neurophysiology next generation novel relating to nervous system research study response sensor tool

项目摘要

DESCRIPTION (provided by applicant): This is an interdisciplinary, innovative technology research and demonstration project to develop the next generation of neural probes for implanted recording. Current neural probes record electrical signals with the use of multiple silicon micromachined electrodes. In an advancement in this field, supported by previous NIH funding, we have demonstrated miniature neurochemical sensors and developed the specialized VLSI integrated circuitry needed to enable chemical measurements from multiple electrodes in a microprobe assembly. The next challenge is to research methods to harvest power to energize the implanted sensor and circuitry. Towards this goal, we propose two innovative technologies 1) the development of a rechargeable, microbattery system capable of sustaining power to the sensor and circuitry, 2) development of a novel VLSI wireless power harvesting circuit to energize the battery. Our other aims are to 3) develop an integrated probe with neurochemical sensor, VLSI wireless interface, power harvesting circuit and microbattery, and 4) evaluate the probe in a model of global ischemic brain injury. This research contributes to our long term goal to build fully implantable, autonomous microprobes, without any tethering, for neurochemical recording in chronically instrumented and tether less animals. A fully self-powered implanted neural microprobe system will be an enabling tool in the hands of neuroscientists interested in recording neural activity from animal models of brain function or brain disorders with the use of microelectrode arrays.

描述（由申请人提供）：这是一个跨学科的创新技术研究和示范项目，旨在开发下一代用于植入记录的神经探针。当前的神经探针使用多个硅微加工电极记录电信号。在该领域的一项进展中，在 NIH 先前资助的支持下，我们展示了微型神经化学传感器，并开发了实现微探针组件中多个电极化学测量所需的专用 VLSI 集成电路。下一个挑战是研究收集能量来为植入的传感器和电路供电的方法。为了实现这一目标，我们提出了两项创新技术：1) 开发能够为传感器和电路持续供电的可充电微电池系统，2) 开发新型 VLSI 无线功率收集电路来为电池供电。我们的其他目标是 3) 开发一种带有神经化学传感器、VLSI 无线接口、能量收集电路和微电池的集成探针，以及 4) 在全球缺血性脑损伤模型中评估探针。这项研究有助于实现我们的长期目标，即构建完全可植入的自主微探针，无需任何束缚，用于长期仪器和无束缚动物的神经化学记录。完全自供电的植入神经微探针系统将成为神经科学家手中的一个有利工具，他们有兴趣使用微电极阵列记录脑功能或脑疾病动物模型的神经活动。