In-Vivo Study of an Oxirane Low Shrink-Stress Composite

环氧乙烷低收缩应力复合材料的体内研究

• 批准号: 7095129
• 负责人: John Henry Purk
• 金额: $ 13.23万
• 依托单位: UNIVERSITY OF MISSOURI KANSAS CITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7095129
• 关键词: Raman spectrometry; biomaterial evaluation; biomaterial interface interaction; clinical research; composite resins; dental adhesive /sealant; dental material wear; ethylene oxide; human subject; information systems; longitudinal human study; outcomes research; patient oriented research; restorative dentistry; scanning electron microscopy; silicon compounds; tensile strength

DESCRIPTION (provided by applicant): John H. Purk is a practicing general dentist. Since 1983 he has taught Operative Dentistry full time at UMKC School of Dentistry. In 2002, he completed an Indisciplinary PhD in Oral Biology/Engineering. His dissertation was an in-vivo clinical research study. His immediate goal is to develop into an independent clinical researcher who can design, organize, characterize the dentin adhesive interface, and conduct clinical research. His long term goal is to train young investigators how to conduct clinical research and conduct translational research. This application is divided into two areas; research career development plan (didactic) and clinical research project. The first didactic component will provide coursework that includes clinical research training in the designing, implementing, analysis and assessment of clinical trials stressing the importance of epidemiology, biostatistics and analysis of data. Additional coursework in micro-Raman spectroscopy in order to characterize the infiltration of the adhesive resin at the adhesive-dentin (a/d) interface will be undertaken. The second didactic experiential component is intended to help the principal investigator observe how didactic information is integrated into an ongoing clinical research project at a study center and also for the principal investigator to set up an in-vitro lab which can simulate positive pulpal pressure to simulate in-vivo conditions. These courses and experiences will allow the candidate to develop independence and expertise in designing and conducting simulated in-vivo and clinical research. The research part combines 1. a preliminary in-vitro pilot study and 2. an in-vivo pilot evaluation of a new emerging low shrink/low stress siloxirane adhesive system for the restoration of interproximal caries in the permanent teeth of children and adults. An in-vitro mechanical and morphologic analyses of these in-vivo restorations following their extraction will also occur. The candidate will develop a unique database for the new dental adhesive composite system that includes clinical features e.g. post-op sensitivity, microtensile bond strength, quantitative information on resin infiltration and void formation at the (aid) interface. The analysis of this data will provide critical, new data on changes within the (a/d) interface which will help researchers evaluate the biomaterials science, and the polymerization and stress properties of a new emerging low shrink/low stress siloxirane adhesive technology. The overall hypotheses of this project are that the clinical performance of class II composite restorations placed in permanent premolars depends on the development of a satisfactory bond at the gingival margin and that a new low shrink/low stress dentin adhesive and resin composite will result in a superior bond at the gingival margin of the class II resin composite restoration. The specific aims will test the following hypotheses: A new low shrink/low stress adhesive siloxirane resin adhesive system compared to a traditional Bis-GMA resin composite system will have a greater microtensile bond strength and adhesive penetration to the gingival wall of class II composite restorations and less void formation at the (a/d) interface.

描述（由申请人提供）：John H. Purk 是一名执业普通牙医。自 1983 年以来，他在 UMKC 牙科学院全职教授手术牙科。 2002 年，他获得了口腔生物学/工程学科博士学位。他的论文是一项体内临床研究。他的近期目标是发展成为一名独立的临床研究员，能够设计、组织、表征牙本质粘合界面，并进行临床研究。他的长期目标是培训年轻研究人员如何进行临床研究和转化研究。该应用程序分为两个区域；研究职业发展计划（教学）和临床研究项目。 第一个教学部分将提供课程，包括临床试验设计、实施、分析和评估方面的临床研究培训，强调流行病学、生物统计学和数据分析的重要性。将进行额外的显微拉曼光谱课程，以表征粘合剂树脂在粘合剂-牙本质 (a/d) 界面的渗透情况。第二个教学体验部分旨在帮助主要研究者观察如何将教学信息整合到研究中心正在进行的临床研究项目中，并帮助主要研究者建立一个可以模拟牙髓正压的体外实验室来模拟体内条件。这些课程和经验将使候选人能够在设计和进行模拟体内和临床研究方面培养独立性和专业知识。 该研究部分结合了 1. 初步体外试点研究和 2. 对用于修复儿童和成人恒牙邻间龋齿的新型低收缩/低应力硅氧烷粘合剂系统的体内试点评估。还将对这些体内修复体提取后进行体外机械和形态学分析。候选人将为新型牙科粘合剂复合系统开发一个独特的数据库，其中包括临床特征，例如：术后敏感性、微拉伸粘合强度、树脂渗透的定量信息和（辅助）界面处的空隙形成。对这些数据的分析将提供有关 (a/d) 界面内变化的关键新数据，这将有助于研究人员评估生物材料科学以及新兴的低收缩/低应力硅氧烷粘合剂技术的聚合和应力特性。该项目的总体假设是，放置在永久前磨牙中的 II 类复合修复体的临床性能取决于牙龈边缘令人满意的粘合的发展，并且新的低收缩/低应力牙本质粘合剂和树脂复合材料将导致II 类树脂复合修复体的牙龈边缘具有优异的粘合力。具体目标将测试以下假设： 与传统的 Bis-GMA 树脂复合材料系统相比，新型低收缩/低应力粘合剂硅氧烷树脂粘合剂系统将具有更大的微拉伸粘合强度和对 II 类复合材料修复体牙龈壁的粘合剂渗透力(a/d) 界面处形成的空隙较少。