In-Vivo Study of an Oxirane Low Shrink-Stress Composite

环氧乙烷低收缩应力复合材料的体内研究

• 批准号: 7468416
• 负责人: John Henry Purk
• 金额: $ 13.23万
• 依托单位: UNIVERSITY OF MISSOURI KANSAS CITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7468416
• 关键词: Acids; Address; Adhesives; Adult; Area; Better Bond; Bicuspid; Biocompatible Materials; Biometry; Bis-GMA Polymer; Chemistry; Child; Class; Clinical; Clinical Research; Clinical Trials; Color; Composite Resins; Condition; Data; Data Analyses; Databases; Dental Cavity Preparation; Dental Enamel; Dental caries; Dentin; Dentists; Development; Development Plans; Doctor of Philosophy; Educational process of instructing; Engineering; Epidemiology; Ethanol; Ethylene Oxide; Evaluation; Failure; Fracture; General Practices; Gingiva; Goals; Hour; In Vitro; Infiltration; Lead; Lifting; Liquid substance; Location; Mechanics; Methacrylates; Modification; Object Attachment; Operative Dentistry; Penetration; Performance; Pilot Projects; Placement; Plant Resins; Preparation; Principal Investigator; Property; Raman Spectrum Analysis; Recurrence; Research; Research Personnel; Research Project Grants; Research Training; Sampling; Scanning Electron Microscopy; School Dentistry; Science; Simulate; Specimen; Statistically Significant; Stress; Surface; System; Technology; Testing; Time; Tooth structure; Training; Training Activity; Translational Research; Urination; Water; Week; base; career; composite restoration; dental adhesive; design; experience; improved; in vivo; oral biology; permanent tooth; polymerization shrinkage; polymerization stress; pressure; programs; research study; restoration; success

DESCRIPTION (provided by applicant): John H. Purk is a practicing general dentist. Since 1983 he has taught Operative Dentistry full time at UMKC School of Dentistry. In 2002, he completed an Indisciplinary PhD in Oral Biology/Engineering. His dissertation was an in-vivo clinical research study. His immediate goal is to develop into an independent clinical researcher who can design, organize, characterize the dentin adhesive interface, and conduct clinical research. His long term goal is to train young investigators how to conduct clinical research and conduct translational research. This application is divided into two areas; research career development plan (didactic) and clinical research project. The first didactic component will provide coursework that includes clinical research training in the designing, implementing, analysis and assessment of clinical trials stressing the importance of epidemiology, biostatistics and analysis of data. Additional coursework in micro-Raman spectroscopy in order to characterize the infiltration of the adhesive resin at the adhesive-dentin (a/d) interface will be undertaken. The second didactic experiential component is intended to help the principal investigator observe how didactic information is integrated into an ongoing clinical research project at a study center and also for the principal investigator to set up an in-vitro lab which can simulate positive pulpal pressure to simulate in-vivo conditions. These courses and experiences will allow the candidate to develop independence and expertise in designing and conducting simulated in-vivo and clinical research. The research part combines 1. a preliminary in-vitro pilot study and 2. an in-vivo pilot evaluation of a new emerging low shrink/low stress siloxirane adhesive system for the restoration of interproximal caries in the permanent teeth of children and adults. An in-vitro mechanical and morphologic analyses of these in-vivo restorations following their extraction will also occur. The candidate will develop a unique database for the new dental adhesive composite system that includes clinical features e.g. post-op sensitivity, microtensile bond strength, quantitative information on resin infiltration and void formation at the (aid) interface. The analysis of this data will provide critical, new data on changes within the (a/d) interface which will help researchers evaluate the biomaterials science, and the polymerization and stress properties of a new emerging low shrink/low stress siloxirane adhesive technology. The overall hypotheses of this project are that the clinical performance of class II composite restorations placed in permanent premolars depends on the development of a satisfactory bond at the gingival margin and that a new low shrink/low stress dentin adhesive and resin composite will result in a superior bond at the gingival margin of the class II resin composite restoration. The specific aims will test the following hypotheses: A new low shrink/low stress adhesive siloxirane resin adhesive system compared to a traditional Bis-GMA resin composite system will have a greater microtensile bond strength and adhesive penetration to the gingival wall of class II composite restorations and less void formation at the (a/d) interface.

描述（由申请人提供）：John H. Purk是一名执业牙医。自1983年以来，他就在UMKC牙科学校全职教手术牙科。 2002年，他获得了口腔生物学/工程学的非学科博士学位。他的论文是一项体内临床研究。他的近期目标是发展成独立的临床研究人员，他可以设计，组织，表征牙本质粘合剂界面并进行临床研究。他的长期目标是培训年轻的研究人员如何进行临床研究和进行转化研究。该应用程序分为两个领域；研究职业发展计划（教学）和临床研究项目。 第一个教学成分将提供课程，其中包括在设计，实施，分析和评估临床试验中强调流行病学，生物统计学和数据分析的重要性的临床研究培训。将进行微摩曼光谱的其他课程工作，以表征将在粘合剂丁丁（A/D）界面上浸润粘合剂树脂的渗透。第二个教学经验成分旨在帮助主要研究者观察研究中心的讲义信息如何整合到正在进行的临床研究项目中，并让主要研究人员建立一个体外实验室，该实验室可以模拟正性牙髓压力以模拟积极的牙髓压力以模拟模拟。体内条件。这些课程和经验将使候选人在设计和进行模拟的体内和临床研究方面发展独立性和专业知识。 研究部分结合了1。初步的视野试验研究和2。对新出现的低收缩/低应激硅质粘附系统的体内试点评估，用于恢复儿童和成人持久性牙齿的脑介入龋齿。这些体内修复体发生后，还将进行体外机械和形态学分析。候选人将为包括临床功能的新牙科粘合剂复合系统开发独特的数据库，例如OP后灵敏度，微义键强度，（AID）界面处有关树脂浸润和空隙形成的定量信息。对该数据的分析将提供有关（a/d）界面内变化的关键新数据，该数据将帮助研究人员评估生物材料科学，以及新出现的新出现的低收缩/低应力硅质粘合剂技术的聚合和应力特性。该项目的总体假设是，将永久性前磨牙的II类复合修复体的临床性能取决于在牙龈缘处的令人满意的键的发展，而新的低收缩/低应力/低应力牙本质粘合剂和树脂复合材料将导致A II类树脂复合恢复的牙龈边缘的上键。具体目的将检验以下假设：与传统的BIS-GMA树脂复合系统相比，新的低收缩/低应力粘合剂硅质树脂粘合剂系统将具有更大的微封装强度和粘合剂渗透到II类复合材料的牙龈壁上在（a/d）接口处更少的空隙形成。