Dentin/Adhesive Interface Structure/Property Imaging

牙本质/粘合剂界面结构/性能成像

基本信息

批准号：
7017703
负责人：
YONG WANG
金额：
$ 7.18万
依托单位：
UNIVERSITY OF MISSOURI KANSAS CITY
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-03-01 至 2008-02-28
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): After more than three decades of research, breakdown at the dentin/adhesive (d/a) interface continues to plague the long-term clinical success of Class II composite restorations. A limitation of previous investigations of the interface is that the data was primarily qualitative in nature and that much of the data was collected using destructive techniques which provided a single measurement on one sample. Understanding the mechanisms and interfacial behavior of the d/a interface requires structure/property analyses that are complementary, synergistic and quantitative as well as qualitative. In most laboratories, these complementary analyses are performed on a heterogeneous mix of instrumentation which has been acquired from different manufacturers. Each instrument uses software unique to the vendor and frequently, the data must be stored in a proprietary format. Managing this mass of data, collected in several different formats, becomes a daunting, time-consuming task. Our inability to collect this data in a common format prohibits direct correlation of the complementary results; it impedes our ability to recognize trends in heterogeneous data. The overall hypothesis of this work is that spectral imaging data collected in vendor-specific formats using a variety of analytical techniques can be translated to a common computing platform that allows data sharing among research groups, visualization of relationships in heterogeneous data and the construction of new detailed, quantitative structure/property data images. The specific aims will test the following hypotheses: 1) heterogeneous incompatible data from different analytical instrumentation, e.g., micro-Raman spectroscopy, FTIR spectroscopy and scanning acoustic microscopy, can be translated from vendor-specific formats to a common computing platform and managed without compromising the integrity of the original data; 2) the data convergence provided by this common computing platform will promote and facilitate visualization of relationships; 3) detailed, quantitative structure/property data images can be constructed using the data repository environment offered by this new, common computing platform and using this new imaging platform, the interrelationship between structure and properties can be understood.

描述（由申请人提供）：经过三十多年的研究，牙本质/粘合剂（D/A）界面的细分继续困扰II类复合材料修复体的长期临床成功。对界面的先前研究的局限性是，数据本质上主要是定性的，并且使用破坏性技术收集了许多数据，这些技术在一个样本上提供了单个测量。了解D/A界面的机制和界面行为需要互补，协同和定量和定性的结构/属性分析。在大多数实验室中，这些互补分析是对仪器的异质组合进行的，该仪器已从不同的制造商那里获得。每个仪器都使用供应商独特的软件，并且经常使用数据以专有格式存储。以几种不同格式收集的这一质量数据成为一项令人生畏的，耗时的任务。我们无法以通用格式收集这些数据禁止互补结果的直接相关性；它阻碍了我们识别异质数据趋势的能力。这项工作的总体假设是，使用各种分析技术以供应商特异性格式收集的光谱成像数据可以转化为一个通用的计算平台，该平台允许研究组之间的数据共享，异质数据中的关系的可视化以及新的详细，定量的，定量的，定量的结构/属性数据图像的构建。具体目的将检验以下假设：1）来自不同分析仪器的异质不相容数据，例如，微拉曼光谱，FTIR光谱和扫描声学显微镜，可以从供应商特异性的计算平台和管理不构成原始数据的供应商特异性格式。 2）此通用计算平台提供的数据收敛将促进和促进关系的可视化； 3）可以使用这个新的，常见的计算平台提供的数据存储库环境构建详细的定量结构/属性数据图像，并使用此新成像平台，可以理解结构和属性之间的相互关系。