Electronically Reconfigurable Microfabricated Tetrodes

电子可重构微制造四极管

• 批准号: 7106462
• 负责人: Babak Ziaie
• 金额: $ 14.49万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-03 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106462
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; brain electrical activity; hippocampus; implant; laboratory rat; medical implant science; microelectrodes; bioengineering /biomedical engineering; biomedical equipment development; brain electrical activity; hippocampus; implant; laboratory rat; medical implant science; microelectrodes

DESCRIPTION (provided by applicant): This proposal seeks funding (R21) under the "Neurotechnology Research, Development, and Enhancement" program to develop an electronically reconfigurable microfabricated tetrode array. Under the proposed research, we will design, fabricate, and test a 3D microfabricated electronically reconfigurable tetrode with multiplexing capability for multi-neuronal recording. Each tetrode will consist of four silicon shanks each having eight recording sites. A three transistor analog multiplexer located next to each site allows each one to be individually selected thus reducing the number of leads (to four for an eight channel electrode). This will make possible the eventual creation of electrodes with hundreds of recording sites. We will start with an eight channel electrode as a proof-of-concept. The four shanks are attached to a silicon backend containing the bonding pads through foldable polyimide links. The connecting polyimide links are only partially cured during the fabrication process and their complete curing following the release results in automatic folding into the desired shape. A silicon platform is fabricated to house 16 tetrode assembly resulting in a total of 64 simultaneous recording at any moment. The fabrication process uses a silicon-on-insulator substrate. The active tetrode will be tested in vivo in hippocampal recordings from awake, behaving rats. Hippocampal place cells are well-understood and have been extensively tested with tetrode. This makes them well-suited to testing new technology. Hippocampus has a very well-understood anatomical structure which will allow quantification of the recording location of each site. This makes it an ideal structure with which to test new recording technology.

描述（由申请人提供）：该提案在“神经技术研究，开发和增强”计划下寻求资金（R21），以开发电子可重新配置的微型四极管阵列。在拟议的研究下，我们将设计，捏造和测试3D微型制动的电子可重构四极管，具有多连接能力以用于多神经元记录。每个四极管将由四个硅柄组成，每个硅柄每个都有八个记录位点。位于每个位点旁边的三个晶体管模拟多路复用器允许单独选择每个位点，从而减少铅数（八个通道电极的四个）。这将使最终创建具有数百个录音站点的电极。我们将从八通道电极作为概念验证开始。这四根柄连接到硅后端，该硅通过可折叠的聚酰亚胺链条包含粘结垫。连接的聚酰亚胺链接仅在制造过程中部分治愈，并且在释放后其完整的固化导致自动折叠成所需的形状。硅平台被制造成容纳16个四极管组件，随时共有64个同时记录。制造过程使用硅在绝缘子基材上。活动四极管将在醒着的海马记录中在体内进行测试，表现为大鼠。海马位置细胞被深思熟虑，并且已经用四极管进行了广泛的测试。这使它们非常适合测试新技术。海马有一个非常理理的解剖结构，可以量化每个位置的记录位置。这使其成为测试新录制技术的理想结构。