Electronically Reconfigurable Microfabricated Tetrodes

电子可重构微制造四极管

基本信息

批准号：
7106462
负责人：
Babak Ziaie
金额：
$ 14.49万
依托单位：
PURDUE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-08-03 至 2008-07-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This proposal seeks funding (R21) under the "Neurotechnology Research, Development, and Enhancement" program to develop an electronically reconfigurable microfabricated tetrode array. Under the proposed research, we will design, fabricate, and test a 3D microfabricated electronically reconfigurable tetrode with multiplexing capability for multi-neuronal recording. Each tetrode will consist of four silicon shanks each having eight recording sites. A three transistor analog multiplexer located next to each site allows each one to be individually selected thus reducing the number of leads (to four for an eight channel electrode). This will make possible the eventual creation of electrodes with hundreds of recording sites. We will start with an eight channel electrode as a proof-of-concept. The four shanks are attached to a silicon backend containing the bonding pads through foldable polyimide links. The connecting polyimide links are only partially cured during the fabrication process and their complete curing following the release results in automatic folding into the desired shape. A silicon platform is fabricated to house 16 tetrode assembly resulting in a total of 64 simultaneous recording at any moment. The fabrication process uses a silicon-on-insulator substrate. The active tetrode will be tested in vivo in hippocampal recordings from awake, behaving rats. Hippocampal place cells are well-understood and have been extensively tested with tetrode. This makes them well-suited to testing new technology. Hippocampus has a very well-understood anatomical structure which will allow quantification of the recording location of each site. This makes it an ideal structure with which to test new recording technology.

描述（由申请人提供）：该提案寻求“神经技术研究、开发和增强”计划下的资金（R21），以开发电子可重构微制造四极管阵列。根据拟议的研究，我们将设计、制造和测试具有多神经元记录复用能力的 3D 微制造电子可重构四极管。每个四极将由四个硅柄组成，每个硅柄有八个记录位点。位于每个站点旁边的三晶体管模拟多路复用器允许单独选择每个站点，从而减少引线数量（八通道电极为四根）。这将使最终创建具有数百个记录位点的电极成为可能。我们将从八通道电极开始作为概念验证。四个柄通过可折叠聚酰亚胺链接连接到包含焊盘的硅后端。连接的聚酰亚胺链接在制造过程中仅部分固化，释放后完全固化会自动折叠成所需的形状。硅平台被制造成可容纳 16 个四极组件，从而在任何时刻总共可同时进行 64 个记录。制造工艺使用绝缘体上硅衬底。活性四极管将在清醒、有行为的老鼠的海马记录中进行体内测试。海马位置细胞已被充分理解，并已使用 tetrode 进行了广泛测试。这使它们非常适合测试新技术。海马体具有非常容易理解的解剖结构，可以量化每个部位的记录位置。这使其成为测试新录音技术的理想结构。