An implantable sensor for wireless measurement of interstitial pressure

用于无线测量间质压力的植入式传感器

• 批准号: 8399010
• 负责人: Babak Ziaie
• 金额: $ 17.58万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-12-15 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8399010
• 关键词: Animal Testing; Blood flow; Caliber; Calibration; Clinical; Collaborations; Computers; Data; Devices; Dose; Drug Delivery Systems; Engineering; Frequencies; Funding; Glass; Goals; Human; Hypoxia; Implant; In Vitro; Indiana; Intercellular Fluid; Length; Light; Measurement; Measures; Microfabrication; Monitor; Nanotechnology; Outcome; Oxygen; Partial Pressure; Performance; Pharmaceutical Preparations; Principal Investigator; Radiation; Radiation Oncology; Radiation therapy; Rattus; Research; Resolution; Schools; Side; Solid Neoplasm; Subcutaneous Tissue; Testing; Therapeutic; Therapeutic Agents; Tissues; Tube; Universities; Wireless Technology; Xenograft Model; bevacizumab; capsule; chemotherapeutic agent; chemotherapy; design; implantation; in vivo; interstitial; medical schools; multidisciplinary; oncology; pressure; programs; sensor; tumor

DESCRIPTION (provided by applicant): The goal of this project is to develop an implantable micro-transponder for measurement of interstitial fluid pressure (IFP) in solid tumors. IFP is an important clinical parameter indicating the accessibility of many solid tumors to therapeutic agents. This is in light of the fact that higher levels of IFP in tumors impede the efficient delivery of drugs. In addition to chemotherapy, radiation therapy can also benefit from lowering the IFP by increasing the oxygen partial pressure in hypoxic tumor regions. The ability to measure IFP using an implantable micro-transponder would provide valuable data for evaluating various pharmacological agents used to lower the IFP. In addition, by measuring the IFP, one can tailor the administration of IFP lowering drugs to optimize their efficacy (e.g., administration of the chemotherapeutic agent when the IFP is reduced). During the course of the proposed research we will develop a micro-transponder for wireless measurement of IFP inside solid tumors. The micro-device consists of a capacitive pressure sensor with an integrated Guyton capsule connected to an inductor, thus forming a parallel LC circuit whose resonant frequency is a measure of interstitial pressure. The LC resonator is packaged inside a glass tube (1.5mm in diameter and 1cm in length) with the Guyton capsule side exposed to the tissue. The presence of Guyton capsule allows accurate measurements of IFP following the implantation since interstitial fluid can easily ingress into the device.

描述（由申请人提供）：该项目的目标是开发一种可植入的微应答器，用于测量实体瘤中的间质液压力（IFP）。 IFP 是一个重要的临床参数，表明许多实体瘤对治疗药物的可及性。这是因为肿瘤中较高水平的 IFP 会阻碍药物的有效输送。除了化疗之外，放射治疗也可以通过增加缺氧肿瘤区域的氧分压来降低 IFP。使用植入式微应答器测量 IFP 的能力将为评估用于降低 IFP 的各种药物提供有价值的数据。此外，通过测量 IFP，人们可以调整 IFP 降低药物的给药以优化其功效（例如，当 IFP 降低时给药化疗剂）。在拟议的研究过程中，我们将开发一种微型转发器，用于无线测量实体瘤内的 IFP。该微型设备由电容式压力传感器和连接到电感器的集成盖顿胶囊组成，从而形成并联 LC 电路，其谐振频率是间隙压力的测量值。 LC 谐振器封装在玻璃管（直径 1.5 毫米，长 1 厘米）内，Guyton 胶囊一侧暴露于组织。 Guyton 胶囊的存在可以在植入后准确测量 IFP，因为间质液很容易进入装置。