An implantable sensor for wireless measurement of interstitial pressure

用于无线测量间质压力的植入式传感器

• 批准号: 8399010
• 负责人: Babak Ziaie
• 金额: $ 17.58万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-12-15 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8399010
• 关键词: Animal Testing; Blood flow; Caliber; Calibration; Clinical; Collaborations; Computers; Data; Devices; Dose; Drug Delivery Systems; Engineering; Frequencies; Funding; Glass; Goals; Human; Hypoxia; Implant; In Vitro; Indiana; Intercellular Fluid; Length; Light; Measurement; Measures; Microfabrication; Monitor; Nanotechnology; Outcome; Oxygen; Partial Pressure; Performance; Pharmaceutical Preparations; Principal Investigator; Radiation; Radiation Oncology; Radiation therapy; Rattus; Research; Resolution; Schools; Side; Solid Neoplasm; Subcutaneous Tissue; Testing; Therapeutic; Therapeutic Agents; Tissues; Tube; Universities; Wireless Technology; Xenograft Model; bevacizumab; capsule; chemotherapeutic agent; chemotherapy; design; implantation; in vivo; interstitial; medical schools; multidisciplinary; oncology; pressure; programs; sensor; tumor

DESCRIPTION (provided by applicant): The goal of this project is to develop an implantable micro-transponder for measurement of interstitial fluid pressure (IFP) in solid tumors. IFP is an important clinical parameter indicating the accessibility of many solid tumors to therapeutic agents. This is in light of the fact that higher levels of IFP in tumors impede the efficient delivery of drugs. In addition to chemotherapy, radiation therapy can also benefit from lowering the IFP by increasing the oxygen partial pressure in hypoxic tumor regions. The ability to measure IFP using an implantable micro-transponder would provide valuable data for evaluating various pharmacological agents used to lower the IFP. In addition, by measuring the IFP, one can tailor the administration of IFP lowering drugs to optimize their efficacy (e.g., administration of the chemotherapeutic agent when the IFP is reduced). During the course of the proposed research we will develop a micro-transponder for wireless measurement of IFP inside solid tumors. The micro-device consists of a capacitive pressure sensor with an integrated Guyton capsule connected to an inductor, thus forming a parallel LC circuit whose resonant frequency is a measure of interstitial pressure. The LC resonator is packaged inside a glass tube (1.5mm in diameter and 1cm in length) with the Guyton capsule side exposed to the tissue. The presence of Guyton capsule allows accurate measurements of IFP following the implantation since interstitial fluid can easily ingress into the device.

描述（由申请人提供）：该项目的目的是开发一个可植入的微型反调节器，用于测量实体瘤中的间质流体压力（IFP）。 IFP是一个重要的临床参数，表明许多实体瘤对治疗剂的可及性。鉴于肿瘤中较高水平的IFP阻碍了药物的有效输送。除了化学疗法外，放射治疗还可以通过增加缺氧肿瘤区域的氧部分压力来降低IFP。使用可植入的微型转题器测量IFP的能力将提供有价值的数据，以评估用于降低IFP的各种药理剂。另外，通过测量IFP，可以定制IFP降低药物的施用以优化其疗效（例如，在降低IFP时给予化学治疗剂）。在拟议的研究过程中，我们将开发一个微型反调节器，用于无线测量实体瘤内的IFP。微设备由一个电容压力传感器组成，该电容压力传感器具有连接到电感器的集成的Guyton胶囊，从而形成了平行的LC电路，其谐振频率是衡量间隙压力的量度。 LC谐振器被包装在玻璃管内（直径1.5mm，长1厘米），盖顿胶囊侧暴露于组织。 Guyton胶囊的存在允许在植入后准确测量IFP，因为间质流体可以轻松地进入设备。