IMAGE-GUIDED ROBOTICALLY-POSITIONED TMS SYSTEM

图像引导机器人定位 TMS 系统

• 批准号: 7052214
• 负责人: Jack L. Lancaster
• 金额: $ 10万
• 依托单位: CEREBRAL MAGNETICS, LLC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-15 至 2008-02-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7052214
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; brain electrical activity; clinical biomedical equipment; computer program /software; computer system design /evaluation; electromyography; head; head movements; human data; image guided surgery /therapy; major depression; phantom model; robotics; transcranial magnetic stimulation

DESCRIPTION (provided by applicant): Interest in transcranial magnetic stimulation (IMS) has grown rapidly since its introduction in 1985, with clinicians and researchers worldwide now using IMS. Promising clinical applications include pre-surgical language mapping, and treatment of depression, Parkinson's disease, and Schizophrenia. Promising research applications include reversible-lesion mapping and connectivity analysis. An image-guided, robotically positioned TMS (irTMS) system that provides accurate and precise IMS for both research and clinical applications was developed at the UTHSCSA Research Imaging Center. This is the first system with fully integrated robotic control of IMS. This system additionally provides a full set of features for treatment planning, similar to modern radiation therapy treatment planning. A new irTMS system and robot intended for broader clinical use is now being evaluated. The initial target market for this irTMS system is for treatment of depression, and our specific aims therefore focus on clinical features important for such treatments, which are also unique to TMS/robotics. The aims of this Phase I proposal are to: 1) replicate prior validation studies using the new robot, 2) develop and evaluate single- session multi-site treatments, 3) develop and evaluate within-session head motion correction, and 4) develop and evaluate optimal TMS coil positioning using feedback from EMG. Concurrent with the performance of these aims we will be developing additional safety features and collecting data regarding safe use of the new robot. In Phase II, the irTMS system will be further refined for its first clinical use, TMS treatment of depression. Testing in this Phase I proposal is with a head phantom to simulate the patient, and testing in Phase II will include research in human subjects. This application is in response to the NIHM Topic B "Instrumentation for Basic and Clinical Neurosciences Research" in the omnibus solicitation.

描述（由申请人提供）：自 1985 年推出以来，人们对经颅磁刺激 (IMS) 的兴趣迅速增长，全世界的临床医生和研究人员现在都在使用 IMS。有前景的临床应用包括术前语言映射以及抑郁症、帕金森病和精神分裂症的治疗。有前途的研究应用包括可逆病变绘图和连接分析。 UTHSCSA 研究成像中心开发了一种图像引导、机器人定位的 TMS (irTMS) 系统，可为研究和临床应用提供准确和精确的 IMS。这是第一个完全集成 IMS 机器人控制的系统。该系统还提供一整套用于治疗计划的功能，类似于现代放射治疗的治疗计划。目前正在评估一种用于更广泛临床用途的新型 irTMS 系统和机器人。该 irTMS 系统的最初目标市场是治疗抑郁症，因此我们的具体目标集中于对此类治疗重要的临床特征，这也是 TMS/机器人所独有的。该第一阶段提案的目的是：1）使用新机器人复制先前的验证研究，2）开发和评估单次多部位治疗，3）开发和评估会话内头部运动校正，4）开发并使用 EMG 的反馈评估最佳 TMS 线圈定位。在实现这些目标的同时，我们将开发额外的安全功能并收集有关新机器人安全使用的数据。在第二阶段，irTMS系统将进一步完善，用于其首次临床应用——TMS治疗抑郁症。第一阶段提案中的测试是使用头部模型来模拟患者，第二阶段的测试将包括对人类受试者的研究。此应用程序是对综合征集中 NIHM 主题 B“基础和临床神经科学研究的仪器”的回应。