Miniature digital telemetric bioelectric recording

微型数字遥测生物电记录

• 批准号: 6993198
• 负责人: ANDRE ANTONIO FENTON
• 金额: $ 10万
• 依托单位: BIO-SIGNAL GROUP CORPORATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-23 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6993198
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; brain electrical activity; electrical measurement; laboratory rat; miniature biomedical equipment; telemetry

DESCRIPTION (provided by applicant): We will improve the radio component of an inexpensive, miniature battery-operated digital telemetric system (DT) for new applications in neuroscience. DT exploits commercially available digital audio integrated circuits and protocols to record, digitize, and transmit bioelectric signals without wires. Phase 1 is based on a prototype designed to record the activity of ensembles of single neurons from the brains of freely-moving rats. The DT version 4 (DT4) prototype has 16 inputs, is 10g and operates >4h from an 18g battery. DT4 digitizes signals at 24-bit resolution, allowing signals as small as 10 uVto be resolved. Each input is lowpass filtered (6 kHz) and digitized (12 kHz). The digital signals are combined into a single data stream and the serialized data are then transmitted to a remote DSP-based recording system via either an optical fiber or a 2.4 GHz radio channel. Measurements by DT4 surpass current standards, but the current radio transmission is unreliable when radio frequency interference (RFI) is high due to multi-path reflections and Wi-Fi and Bluetooth devices. Specific aim 1 is to use RRM techniques in the DT for reliable radio transmission. Deliverable 1 is a 2-ch wireless module. Deliverable 2 is a 16-ch wireless system based on eight 2-ch modules. Deliverable 3 is to characterize and test deliverable 2 by recording ensembles of neurons in freely-moving rats. For non-interactive applications, wireless recording is not advantageous if the recording device itself (usually a PC) is not also portable. Specific aim 2 is to build a prototype DT with wireless USB for animal research. A tethered USB version of the DT will be developed for Deliverable 4. Once a wireless USB controller is available, replacing the "wired" USB chipset by its wireless equivalent should be relatively straightforward; if the latter is available, Deliverable 5 will be a prototype DT based on the wireless USB standard. In Phase II, to commercialize the device for neuroscience research we will reduce the device's size and cost and make first steps towards realizing a DT for clinical use.

描述（由申请人提供）：我们将改进廉价、微型电池供电的数字遥测系统（DT）的无线电组件，以用于神经科学的新应用。 DT 利用商用数字音频集成电路和协议来记录、数字化和无线传输生物电信号。第一阶段基于一个原型，旨在记录自由活动大鼠大脑中单个神经元群的活动。 DT 版本 4 (DT4) 原型有 16 个输入，重量为 10g，使用 18g 电池可运行 >4 小时。 DT4 以 24 位分辨率对信号进行数字化，可以解析小至 10 uV 的信号。每个输入均经过低通滤波 (6 kHz) 和数字化 (12 kHz)。数字信号被组合成单个数据流，然后串行数据通过光纤或 2.4 GHz 无线电通道传输到基于 DSP 的远程记录系统。 DT4 的测量结果超出了当前标准，但当射频干扰 (RFI) 由于多路径反射以及 Wi-Fi 和蓝牙设备而较高时，当前的无线电传输并不可靠。具体目标1是在DT中使用RRM技术来实现可靠的无线电传输。交付品 1 是一个 2 通道无线模块。 Deliverable 2 是基于八个 2 通道模块的 16 通道无线系统。交付成果 3 是通过记录自由移动大鼠的神经元集合来表征和测试交付成果 2。对于非交互式应用，如果记录设备本身（通常是 PC）不是便携式的，那么无线记录就没有优势。具体目标 2 是构建一个带有无线 USB 的原型 DT，用于动物研究。 DT 的系留 USB 版本将为 Deliverable 4 开发。一旦无线 USB 控制器可用，用无线等效物替换“有线”USB 芯片组应该相对简单；如果后者可用，Deliverable 5 将成为基于无线 USB 标准的原型 DT。在第二阶段，为了将该设备商业化用于神经科学研究，我们将减小设备的尺寸和成本，并朝着实现临床应用的 DT 迈出第一步。