Miniature digital telemetric bioelectric recording

微型数字遥测生物电记录

• 批准号: 6993198
• 负责人: ANDRE ANTONIO FENTON
• 金额: $ 10万
• 依托单位: BIO-SIGNAL GROUP CORPORATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-23 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6993198
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; brain electrical activity; electrical measurement; laboratory rat; miniature biomedical equipment; telemetry

DESCRIPTION (provided by applicant): We will improve the radio component of an inexpensive, miniature battery-operated digital telemetric system (DT) for new applications in neuroscience. DT exploits commercially available digital audio integrated circuits and protocols to record, digitize, and transmit bioelectric signals without wires. Phase 1 is based on a prototype designed to record the activity of ensembles of single neurons from the brains of freely-moving rats. The DT version 4 (DT4) prototype has 16 inputs, is 10g and operates >4h from an 18g battery. DT4 digitizes signals at 24-bit resolution, allowing signals as small as 10 uVto be resolved. Each input is lowpass filtered (6 kHz) and digitized (12 kHz). The digital signals are combined into a single data stream and the serialized data are then transmitted to a remote DSP-based recording system via either an optical fiber or a 2.4 GHz radio channel. Measurements by DT4 surpass current standards, but the current radio transmission is unreliable when radio frequency interference (RFI) is high due to multi-path reflections and Wi-Fi and Bluetooth devices. Specific aim 1 is to use RRM techniques in the DT for reliable radio transmission. Deliverable 1 is a 2-ch wireless module. Deliverable 2 is a 16-ch wireless system based on eight 2-ch modules. Deliverable 3 is to characterize and test deliverable 2 by recording ensembles of neurons in freely-moving rats. For non-interactive applications, wireless recording is not advantageous if the recording device itself (usually a PC) is not also portable. Specific aim 2 is to build a prototype DT with wireless USB for animal research. A tethered USB version of the DT will be developed for Deliverable 4. Once a wireless USB controller is available, replacing the "wired" USB chipset by its wireless equivalent should be relatively straightforward; if the latter is available, Deliverable 5 will be a prototype DT based on the wireless USB standard. In Phase II, to commercialize the device for neuroscience research we will reduce the device's size and cost and make first steps towards realizing a DT for clinical use.

描述（由申请人提供）：我们将改善用于神经科学新应用的廉价，微型电池经营的数字遥测系统（DT）的无线电组件。 DT利用市售的数字音频集成电路和协议，以记录，数字化和传输无线电的生物电信号。第1阶段基于设计的原型，该原型旨在记录自由移动大鼠大脑的单个神经元的集合的活性。 DT版本4（DT4）原型具有16个输入，为10G，可从18克电池运行> 4H。 DT4以24位分辨率将信号数字化，允许解析10个紫外线的信号。每个输入均为低通滤波（6 kHz）并数字化（12 kHz）。将数字信号组合到单个数据流中，然后通过光纤或2.4 GHz无线电通道将序列化数据传输到基于远程DSP的记录系统。通过DT4的测量值超过电流标准，但是当射频干扰（RFI）高于多路径反射以及Wi-Fi和蓝牙设备时，当前的无线电传输是不可靠的。具体目的1是在DT中使用RRM技术进行可靠的无线电传输。可交付1是一个2-ch无线模块。可交付2是一个基于八个2-ch模块的16 CH无线系统。可交付3是通过记录自由移动大鼠神经元的合奏来表征和测试可交付的2。对于非相互作用的应用程序，如果录制设备本身（通常是PC）也不可移植，则无线记录是不利的。具体目标2是用无线USB构建原型DT进行动物研究。 DT的束缚USB版本将用于可交付4。无线USB控制器可用，用无线等效替换“有线”的USB芯片组应该相对简单；如果后者可用，可交付5将是基于无线USB标准的原型DT。在第二阶段，为了使神经科学研究设备进行商业化，我们将降低设备的尺寸和成本，并迈出第一步，以实现临床使用的DT。