Deep Brain Stimulation Using Microactuated Microprobes

使用微驱动微探针进行深部脑刺激

基本信息

批准号：
7197137
负责人：
JITENDRAN MUTHUSWAMY
金额：
$ 2.84万
依托单位：
ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-04-01 至 2007-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7197137
关键词：
Parkinson&apos s disease bioengineering /biomedical engineering biomedical equipment development brain electrical activity brain electronic stimulator corpus striatum electrical measurement laboratory rat medical implant science microdialysis microelectrodes miniature biomedical equipment substantia nigra

项目摘要

DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) is an FDA approved therapy for essential tremor and Parkinson's disease that provides symptomatic relief over long term. It is also a promising therapy for epilepsy, dyskinesias, obsessive-compulsive and anxiety disorder. However, the efficacy of the DBS therapy is significantly reduced due to difficulties in precisely localizing the stimulation microelectrodes. In addition, lengthy surgical sessions under anesthesia that include electrophysiological observations and radiological methods are often necessary to confirm the microelectrode location. The overall goal of this proposed project is to develop a microactuated microelectrode technology that will enable precise positioning and movement of microelectrodes in behaving animals after implantation for deep brain stimulation. The proposed technology will provide an unprecedented ability to monitor single neuronal electrical activity and behavioral correlates to stimulation in unanesthetized animals while the stimulation electrode is being moved towards the desired target structure. The above capability promises to greatly enhance the precision, efficacy and safety of DBS with implanted microelectrodes. Specifically, we propose to develop a thermal microactuator and associated microelectrode technology for precise positioning and optimal stimulation of the nigro-striatal bundle in behaving rat models of Parkinson's disease. The key technological barriers that must be overcome are (i). Developing microactuator technologies with enough translation capability to interrogate deep brain structures in rodents with sufficient precision in displacement (ii). Development and optimization of an integrated stimulation and recording capability in the nigro-striatal bundle using an array of microactuated microelectrodes. The proposed technology will be tested and validated in rodent models of Parkinson's disease. Successful development of this technology will make microelectrode implantation for deep brain stimulation precise leading to safe and an efficient therapy with shorter surgical times. Future developments of this technology could lead to an efficient delivery vehicle for drug or gene therapy.

描述（由申请人提供）：深脑刺激（DBS）是FDA批准的基本震颤和帕金森氏病的疗法，可长期缓解症状。这也是一种有前途的癫痫，失调，强迫症和焦虑症的疗法。然而，由于难以精确定位刺激微电极，DBS治疗的功效大大降低了。此外，在麻醉下进行冗长的手术课程，包括电生理观察结果和放射学方法以确认微电极位置。该拟议项目的总体目标是开发一种微型微电极技术，该技术将在植入后进行动物以进行深层脑刺激后的行为动物中的微电极的精确定位和运动。所提出的技术将提供前所未有的能力，以监测单个神经元电活动和行为与未经麻醉的动物的刺激相关，而刺激电极正在向所需的目标结构移动。上述能力有望通过植入的微电极大大提高DBS的精度，功效和安全性。具体而言，我们建议开发一种热微型抗体和相关的微电极技术，以精确定位和最佳刺激帕金森氏病大鼠模型中的nigro - 纹状体束。必须克服的关键技术障碍是（i）。开发具有足够翻译能力的显微活性技术，可以在位移（ii）中足够精确的啮齿动物中审问深脑结构。使用一系列微型微电极在跨纹状体捆绑中的综合刺激和记录能力的开发和优化。拟议的技术将在帕金森氏病的啮齿动物模型中进行测试和验证。这项技术的成功开发将使微电极植入以深度刺激精确地刺激，从而导致安全性和有效的手术时期的有效疗法。该技术的未来发展可能会导致有效的药物或基因治疗递送工具。