College of Medicine Phoenix Campus Vivarium Phase I Construction

医学院凤凰城校区动物园一期建设

• 批准号: 7898290
• 负责人: DAVID G BESSELSEN
• 金额: $ 1499.6万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7898290
• 关键词: Animal Experimentation; Animals; Area; Arizona; Award; Beds; Behavioral; Behavioral Assay; Blood; Breeding; Certification; Cities; Containment; Decontamination; Equipment; Euthanasia; Faculty; Food; Future; Health Sciences; Housing; Image; Injection of therapeutic agent; Laboratories; Laboratory Animals; Laboratory Research; Measurement; Medicine; Mus; Occupations; Operative Surgical Procedures; Osmosis; Phase; Physiological; Procedures; Production; Quarantine; Rattus; Recruitment Activity; Recycling; Research; Research Support; Rodent; Silver; Site; System; Telemetry; Tissue Banks; Transgenic Mice; Universities; Water; animal care; climate change; college; exhaust; in vivo; irradiation; medical schools; meetings; metropolitan; operation; science education; segregation

DESCRIPTION (provided by applicant): The University of Arizona College of Medicine - Phoenix in Partnership with Arizona State University (COM-P) recruited its first new faculty to the Phoenix Biomedical Campus in 2006, and currently has 22 faculty with research laboratories in the Arizona Biomedical Collaborative 1 (ABC 1). Animal research by these faculty is currently conducted at various AAALAC-approved vivarium facilities throughout the Phoenix metropolitan area. The specific aim of the present proposal is to support construction of a 12,100 DGSF vivarium on campus to meet existing and future scientific needs. This represents Phase One of a larger vivarium project currently planned for the Phoenix Biomedical Campus along with construction of the Health Sciences Education Building and the ABC 2 research building. The COM-P Phase One Vivarium will include animal holding rooms with a total capacity of 4,158 mouse cages and 1,200 rat cages for rodent housing. Rooms will be provided for breeding of transgenic mice lines, specialized behavioral assays of rats and mice, animal biosafety level 2 (ABSL2) procedures in mice, quarantine of rats and mice, and segregation of rodents returning to the vivarium from laboratories. Specialized suites are included for behavioral analyses, ABSL2 containment and decontamination, and small animal imaging and irradiation. In addition, areas will be dedicated to clean and dirty cage, food and bedding storage; animal receiving; euthanasia and veterinary procedures; surgical facilities, and procedure rooms for physiological measurement, telemetry, injections, blood and tissue collection, and other in vivo procedures. The vivarium will house rodents in Innovive(R) individually ventilated, disposable (recyclable) caging systems. In addition, locker rooms with restrooms and showers, a staff room and office are provided. Fixed, major equipment requested includes: two Class 2, Type B2 fully exhausted biosafety cabinets, seven Class 2, Type A2 biosafety cabinets, an autoclave, examination lamps, and a reverse osmosis Hydropak water pouch production system. In accordance with the Initiative on Climate Change, signed by the participating University Presidents, this project will pursue LEED Silver certification with sustainability concepts, including recycling, energy efficiency, reduced water use and sustainable site and open space plans. The COM-P Phase One Vivarium will provide much needed facilities in support of existing PHS research at a new and rapidly growing medical college located in the fifth largest U.S. city. Timely award and construction of the project will create or retain 126 jobs, with ongoing operations of the facility creating or retaining 18 jobs. The best and only way to assure optimal standards of experimental animal care required for our PHS-supported research efforts is to construct this dedicated laboratory animal vivarium serving the Phoenix Biomedical Campus.

描述（由申请人提供）：亚利桑那大学医学院 - 凤凰城与亚利桑那州立大学（COM -P）合作，于2006年招募了其第一个新的教职员工到凤凰生物医学校园，目前与亚利桑那州生物医学协作1（ABC 1）的研究实验室有22位。这些学院的动物研究目前在整个凤凰城都会区的各种AAALAC批准的Vivarium设施进行。本提案的具体目的是支持在校园内建造12,100个DGSF Vivarium，以满足现有和未来的科学需求。这代表了目前为凤凰生物医学校园计划的较大的Vivarium项目的第一阶段，以及健康科学教育大楼和ABC 2研究大楼的建设。 COM-P第一阶段的Vivarium将包括4,158个小鼠笼子和1,200大鼠笼子的啮齿动物饲养室。将提供房间，用于繁殖转基因小鼠线，专门的大鼠和小鼠行为测定，动物生物安全2级（ABSL2）手术（ABSL2）手术，大鼠和小鼠的隔离以及从实验室返回的啮齿动物的啮齿动物的隔离。专门的套件包括用于行为分析，ABSL2遏制和净化以及小动物成像和照射。此外，区域将致力于清洁和肮脏的笼子，食物和床上用品储存；动物接收；安乐死和兽医程序；用于生理测量，遥测，注射，血液和组织以及其他体内手术的手术设施和程序室。 Vivarium将在创新（R）单独通风，一次性（可回收）笼子系统中容纳啮齿动物。此外，还提供带洗手间和淋浴的更衣室，提供员工室和办公室。固定的，要求的主要设备包括：两种2类，B2型全耗尽的生物安全柜，七个级别2，A2型生物安全柜，一台高压灭菌器，检查灯和一个反渗透渗透的Hydropak水袋生产系统。根据参与大学校长签署的关于气候变化的计划，该项目将通过可持续性概念进行LEED银牌认证，包括回收利用，能源效率，减少用水以及可持续的现场和开放空间计划。 COM-P第一阶段的Vivarium将提供急需的设施，以支持位于美国第五大城市的新的，快速发展的医学院的现有PHS研究。该项目的及时奖励和建设将创造或保留126个工作岗位，该设施的持续运营创造或保留18个工作岗位。确保我们pHS支持的研究工作所需的最佳实验动物护理标准的最佳和唯一方法是建造为凤凰生物医学校园服务的专门实验室动物。