How Does Osteocalcin Reverse Glucocorticoid-Induced Dysmetabolism?

骨钙素如何逆转糖皮质激素引起的代谢异常？

• 批准号: nhmrc : GNT1086100
• 负责人: Dr Michael Swarbrick
• 金额: $ 61.52万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-osteocalcin-reverse-induced-dysmetabolism/1345650
• 关键词: How; Does; Osteocalcin; Reverse; Glucocorticoid

The benefits of glucocorticoids (GCs) are often compromised by adverse effects such as bone loss, diabetes & obesity. There is now evidence that osteocalcin regulates fuel metabolism. Osteocalcin may therefore be a potential target to prevent the adverse metabolic effects of GC therapy. We aim to determine how osteocalcin regulates energy metabolism in adipose tissue and the liver under conditions of GC excess, and whether and how osteocalcin acts through a G-protein coupled receptor.

糖皮质激素 (GC) 的益处常常会因骨质流失、糖尿病和肥胖等副作用而受到损害。现在有证据表明骨钙素调节燃料代谢。因此，骨钙素可能是预防 GC 治疗不良代谢效应的潜在靶点。我们的目标是确定骨钙素如何在 GC 过量的情况下调节脂肪组织和肝脏的能量代谢，以及骨钙素是否以及如何通过 G 蛋白偶联受体发挥作用。