Age-Related Changes in Body Composition and Fuel Metabolism: The Role of Glucocorticoid Signalling in Osteoblasts

与年龄相关的身体成分和燃料代谢变化：糖皮质激素信号在成骨细胞中的作用

• 批准号: nhmrc : 1101879
• 负责人: Dr Michael Swarbrick
• 金额: $ 56.42万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/age-related-changes-signalling-osteoblasts/662574
• 关键词: Age; Related; Changes; Body; Composition

Our previous studies suggest that age related changes in fat tissue could be due to an increased level of glucocorticoids within bone forming cells (osteoblasts). Mice in which the level of glucocorticoids in osteoblasts is selectively decreased were no different from normal mice at a young age but with ageing were protected against development of obesity and diabetes. This project will examine how bone influences age related changes in fat mass and examine ways in which this might be prevented.

我们之前的研究表明，脂肪组织中与年龄相关的变化可能是由于骨形成细胞（成骨细胞）内糖皮质激素水平增加所致。成骨细胞中糖皮质激素水平选择性降低的小鼠在年轻时与正常小鼠没有什么不同，但随着年龄的增长，它们可以防止肥胖和糖尿病的发生。该项目将研究骨骼如何影响与年龄相关的脂肪量变化，并研究预防这种变化的方法。