Dietary pattern indexes: relation with CVD risk factors

膳食模式指数：与CVD危险因素的关系

基本信息

批准号：
6662549
负责人：
ASHIMA K KANT
金额：
$ 11.55万
依托单位：
QUEENS COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-30 至 2005-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6662549
关键词：
atherosclerosis behavioral /social science research tag cardiovascular disorder risk clinical research coronary disorder diet health behavior human data lifestyle nutrient interaction nutrition related tag

项目摘要

DESCRIPTION (provided by applicant): Although many studies have examined the role of single nutrients, foods, or food groups in the etiology of disease, relatively little research has addressed the health effects of dietary patterns comprising multiple interdependent dietary factors. Research on dietary patterns is warranted on several grounds. First, complex diets consumed by free-living individuals do not consist of single nutrients or foods but rather a combination of foods containing multiple nutrients and non-nutrients. Second, intercorrelation of dietary variables makes it difficult to isolate effects of single nutrients or foods. Third, biological activities of nutrients in vivo are interdependent. Finally, recommendations for disease prevention implicitly reflect the dietary pattern approach by emphasizing the simultaneous change of several dietary behaviors such as increasing fruit, vegetable, and grain intake, and decreasing fat intake. However, the exact mechanisms through which healthy diet patterns modify the risk of heart disease are not known. Intuitively, such patterns may be effective at several levels, but little is known about it. This proposal will test the hypothesis that two diet indexes intended to represent healthy eating patterns may be associated with several major, life-habit, and emerging risk factors of coronary heart disease (CHD) risk identified by the ATP III in a representative sample of adult Americans. We will use dietary, anthropometric, biochemical, and health data from the third National Health and Nutrition Examination Survey, 1988-1994 (>15,000), to address these issues.

描述（由申请人提供）：尽管许多研究探讨了单一营养素、食物或食物组在疾病病因中的作用，但相对较少的研究探讨了由多种相互依赖的饮食因素组成的饮食模式对健康的影响。对饮食模式的研究有几个理由。首先，自由生活的个体消耗的复杂饮食并不包含单一营养素或食物，而是包含多种营养素和非营养素的食物组合。其次，饮食变量的相互关联使得很难分离单一营养素或食物的影响。第三，营养素在体内的生物活性是相互依存的。最后，疾病预防建议通过强调同时改变多种饮食行为（例如增加水果、蔬菜和谷物摄入量以及减少脂肪摄入量）隐含地反映了饮食模式方法。然而，健康饮食模式改变心脏病风险的确切机制尚不清楚。直观上，这种模式可能在多个层面上有效，但人们对此知之甚少。该提案将检验以下假设：旨在代表健康饮食模式的两个饮食指数可能与 ATP III 在成人代表性样本中确定的冠心病 (CHD) 风险的几个主要、生活习惯和新出现的危险因素相关。美国人。我们将使用 1988-1994 年第三次全国健康和营养检查调查（>15,000）的饮食、人体测量、生化和健康数据来解决这些问题。