Relation of diet quality with mortality

饮食质量与死亡率的关系

基本信息

批准号：
6645159
负责人：
ASHIMA K KANT
金额：
$ 7.7万
依托单位：
QUEENS COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-08-01 至 2003-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6645159
关键词：
atherosclerosis breast neoplasms cancer risk cardiovascular disorder epidemiology cerebrovascular disorders colorectal neoplasms coronary disorder diet human data human mortality lung neoplasms neoplasm /cancer epidemiology nutrition related neoplasm /cancer nutrition related tag

项目摘要

Although many studies have examined the role of single nutrients, foods, or food groups in the etiology of disease, relatively little research has addressed the health effects of dietary patterns comprising multiple interdependent dietary factors. Research on dietary patterns is warranted on several grounds. First, complex diets consumed by free-living individuals do not consist of single nutrients or foods but rather a combination of foods containing multiple nutrients and non-nutrients. Second, intercorrelation of dietary variables makes it difficult to isolate effects of single nutrients or foods. Third, in vivo biological activities of nutrients are interdependent. Finally, recommendations for disease prevention implicitly reflect the dietary pattern approach by emphasizing the simultaneous change of several dietary behaviors such as increasing fruit, vegetable, and grain intake, and decreasing fat intake. The purpose of this small grant proposal is to analyze data from two large national cohorts [National Health Interview Surveys of 1987 (n=22,080; 2937 deaths due to all causes), and 1992 (n=12,005; 1033 deaths due to all causes)] to examine prospectively the relation of overall diet quality to all-cause and, cause-specific mortality. Measures of overall diet quality developed from food frequency questionnaire collected as a supplement to the core survey will be examined in relation to risk of mortality over a followup period of 5-10 years. Cox's proportional hazards regression analysis will be used to test the independent association of diet quality with each outcome using statistical software (SUDAAN) appropriate for analysis of data from surveys with a complex study design.

尽管许多研究探讨了单一营养素、食物或食物组在疾病病因中的作用，但相对较少的研究探讨了由多种相互依赖的饮食因素组成的饮食模式对健康的影响。对饮食模式的研究有几个理由。首先，自由生活的个体消耗的复杂饮食并不包含单一营养素或食物，而是包含多种营养素和非营养素的食物组合。其次，饮食变量的相互关联使得很难分离单一营养素或食物的影响。第三，体内营养物质的生物活性是相互依存的。最后，疾病预防建议通过强调同时改变多种饮食行为（例如增加水果、蔬菜和谷物摄入量以及减少脂肪摄入量）隐含地反映了饮食模式方法。这项小额赠款提案的目的是分析来自两个大型国家队列的数据[1987 年全国健康访谈调查（n=22,080；2937 例因各种原因死亡）和 1992 年（n=12,005；1033 例因各种原因死亡） ] 前瞻性地研究总体饮食质量与全因死亡率和特定原因死亡率的关系。根据作为核心调查补充而收集的食物频率调查问卷制定的总体饮食质量衡量标准将在 5-10 年的随访期内与死亡风险相关联进行检查。 Cox 的比例风险回归分析将用于测试饮食质量与每个结果的独立关联，使用适合分析复杂研究设计的调查数据的统计软件 (SUDAAN)。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

CD33 expression and P-glycoprotein-mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy.

CD33 表达和 P-糖蛋白介导的药物流出负相关并预测接受吉妥珠单抗奥佐米星单药治疗的急性髓系白血病患者的临床结果。

DOI：
发表时间：
2007-05-15
期刊：
影响因子：
20.3
作者：
Walter, Roland B;Gooley, Ted A;van der Velden, Vincent H J;Loken, Michael R;van Dongen, Jacques J M;Flowers, David A;Bernstein, Irwin D;Appelbaum, Frederick R
通讯作者：
Appelbaum, Frederick R

Dietary patterns predict mortality in a national cohort: the National Health Interview Surveys, 1987 and 1992.

饮食模式可预测全国队列中的死亡率：1987 年和 1992 年全国健康访谈调查。