Determinants of Schistosomiasis Re-emergence

血吸虫病复发的决定因素

• 批准号: 7795828
• 负责人: ROBERT C SPEAR
• 金额: $ 44.62万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7795828
• 关键词: Agriculture; Animals; Area; Case-Control Studies; Characteristics; China; Communicable Diseases; County; Data; Dependence; Development; Early Diagnosis; Environment; Event; Fertilization; Frequencies; Habitats; Human; Individual; Infection; Irrigation; Knowledge; Lead; Link; Location; Methods; Modeling; Monitor; Nature; Parasites; Persons; Principal Investigator; Probability; Process; Province; Public Health; Recording of previous events; Records; Research; Research Personnel; Resources; Risk; Schistosomiasis; Schistosomiasis japonica; Site; Snails; Source; Surveillance Program; System; Testing; Time; Water; Work; base; density; design; experience; field study; indexing; mathematical model; migration; programs; public health research; remote sensing; tool; transmission process

DESCRIPTION (provided by applicant): The broad long-term objectives of our research on the transmission and control of Schistosoma japonicum infections in China have been to develop methods for the design of site-specific control programs to achieve the sustainable cessation of transmission. The recent re-emergence of transmission in formerly controlled counties has prompted this proposal, in which we extend our objectives to include an understanding of the determinants of re-emergence, which will inform the design of surveillance programs for the early detection and minimization of the scale and impact of re-emergence. The aims of our research are to 1. Test the hypothesis that re-emergence is driven by two village-level factors: internal potential (a village's inherent ability to support transmission that includes snail density, human and animal hosts, and agricultural practices) and connectivity (factors related to the introduction of parasites from endemic areas), which can be obtained from existing historical records and remote sensing; 2. Using a case-control study, test the hypothesis that individual-level within-village and outside-village water contact is predictive of the initial infections in re-emergent villages; and 3. Utilize a stochastic model of re-emergent transmission to explore the effect of chance events on the design of an effective surveillance system. Relevance to public health: This research is relevant to public health, in that it will increase our knowledge of the factors related to infectious disease re-emergence. Through this understanding, better surveillance approaches can be developed to protect public health.

描述（由申请人提供）：我们研究中国japonicum感染的传播和控制的研究的广泛长期目标是开发设计特定地点控制计划的方法，以实现传播的可持续停止。最近在以前受控县中传播的重新出现促使了这一提议，在该提议中，我们将目标扩展到包括对重新出现的决定因素的理解，这将为监视计划设计，以提高监视计划的早期检测和最小化重新范围和重新出现的影响。我们的研究的目的是1。检验以下假设：重新出口是由两个村庄级别的因素驱动的：内部潜力（村庄的固有能力，包括蜗牛密度，人类和动物宿主，人类和农业实践）和连接性（与从事历史记录和远程记录中引入寄生虫有关的因素（与引入寄生虫引入的因素）（有关因素）； 2。使用案例对照研究，检验以下假设：个体级别的内部村内和村外水接触可预测重新出现村庄的初始感染； 3。利用重新发射器传播的随机模型来探讨机会事件对有效监视系统设计的影响。与公共卫生的相关性：这项研究与公共卫生有关，因为它将增加我们对与传染病再生有关的因素的了解。通过这种理解，可以开发出更好的监视方法来保护公共卫生。