High Resolution Imaging Detector for Mammography

用于乳腺 X 线摄影的高分辨率成像探测器

• 批准号: 6951127
• 负责人: GERALD ENTINE
• 金额: $ 35万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-20 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6951127
• 关键词: X ray; bioimaging /biomedical imaging; biomedical equipment development; breast neoplasm /cancer diagnosis; breast neoplasms; charge coupled device camera; diagnosis design /evaluation; digital imaging; early diagnosis; image processing; lead; mammography

DESCRIPTION (provided by applicant): Breast carcinoma is the leading cause of cancer in women in the U.S. It is well known that if breast cancer is detected when the tumor is small and axillary nodes are not involved, the survival rate is very high. However, if the cancer has spread with time, the survival rate drops significantly. Early detection of breast tumors is therefore critical to the successful treatment of breast cancer and significant reduction in the breast cancer mortality rate (30 to 50%) can be achieved through early detection of breast carcinoma by X-ray mammography. X-ray mammography is currently performed using a film-screen system and while it has shown good success in detecting early stage, clinically occult breast cancer, the film-screen detector has limited latitude and dynamic range. Its performance is also affected by trade-off between detection efficiency and spatial resolution due to increased light spreading in thicker screens which are more efficient in stopping X-rays. In view of these limitations, we plan to explore a novel digital imaging detector for mammography.

描述（由申请人提供）： 乳腺癌是美国女性癌症的主要原因，众所周知，如果检测到肿瘤小时，并且不涉及腋窝淋巴结，则存活率很高。但是，如果癌症随时间扩散，生存率会大大下降。因此，乳腺肿瘤的早期检测对于成功治疗乳腺癌至关重要，并且可以通过X射线乳房X线摄影来早期检测乳腺癌来实现乳腺癌死亡率的显着降低（30至50％）。 X射线乳房X线摄影目前是使用膜屏幕系统进行的，尽管它在检测早期阶段，临床上隐匿性乳腺癌方面取得了良好的成功，但膜屏幕检测器的纬度和动态范围有限。由于较厚的屏幕上的光扩展增加，在X射线效率上更有效，其性能也受到检测效率和空间分辨率之间的权衡影响。鉴于这些局限性，我们计划探索一种新颖的数字成像探测器来进行乳房X线摄影。