Compact X-ray Station for Protein Crystallography

用于蛋白质晶体学的紧凑型 X 射线站

• 批准号: 6933372
• 负责人: RODERICK J LOEWEN
• 金额: $ 64.94万
• 依托单位: LYNCEAN TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6933372
• 关键词: X ray crystallography; bioengineering /biomedical engineering; biomedical equipment development; electromagnetic radiation; macromolecule; miniature biomedical equipment; optics; synchrotrons

DESCRIPTION (provided by applicant): The purpose of this Fast-Track SBIR is to develop an innovative Compact X-ray Station (CXS) for macromolecular crystallography. This station accepts the output x-ray beam of the Compact Light Source, a miniature synchrotron, and delivers x-ray beams to 3 end stations. Each beamline accommodates an integrated commercial diffractometer. Each of 2 side stations receives a tunable, monochromatic x-ray beam in a 30 micron rms spot. The forward station receives a focused higher-flux narrow band x-ray beam. Each of the x-ray beams is tunable from 7 to 16 keV and will provide a flux and energy resolution comparable to synchrotron beamlines. The beamlines can be run separately, in pairs or all 3 simultaneously. In Phase I, we will design the x-ray optics systems and experimentally test a new, tunable focusing monochromator. In Phase II, we will build the x-ray optics and end stations, integrate a commercial diffractometer and fully test the end stations. The CXS is an innovative, powerful, 'turn key' x-ray system which will provide a home laboratory with 3 'synchrotron' beamlines for macromolecular crystallography; 2 beamlines will have the flux, tunability, and energy resolution for single- or multi-wavelength anomalous dispersion experiments, and the third beamline will be optimized for higher-flux screening.

描述（由申请人提供）：此快速轨道SBIR的目的是为大分子晶体学开发创新的紧凑型X射线站（CXS）。该站接受紧凑型光源的输出X射线束，微型同步器，并将X射线梁传递到3个端站。每个光束线可容纳一个集成的商业衍射仪。 2个侧站中的每一个都以30微米的RMS斑点接收一个可调的单色X射线梁。向前站接收一个聚焦的高速频带X射线梁。每个X射线梁都可以从7到16 KEV调谐，并且将提供与同步束线相当的通量和能量分辨率。梁线可以同时分别分别以成对或所有3个。在第一阶段，我们将设计X射线光学系统，并通过实验测试一个新的可调焦点单色器。在第二阶段，我们将构建X射线光学元件和端站，集成商业衍射仪并进行完全测试端站。 CXS是一种创新，功能强大的“转向钥匙” X射线系统，它将为大分子晶体学的3'同步器'梁线提供一个家庭实验室； 2个梁线将具有单或多波长异常分散实验的通量，可调性和能量分辨率，并且将优化第三个梁线以进行更高频率筛选。