A Tunable, Tabletop, Synchrotron Light Source

可调谐桌面同步加速器光源

• 批准号: 6752641
• 负责人: JEFFREY RIFKIN
• 金额: $ 355.84万
• 依托单位: LYNCEAN TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2005-02-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6752641
• 关键词: X ray; X ray crystallography; bioengineering /biomedical engineering; biomedical equipment development; computer system design /evaluation; energy source; lasers; optics; synchrotrons

DESCRIPTION (provided by applicant): Intense x-rays from Synchrotron Radiation sources are having an increasingly revolutionary impact on science and technology, and in particular, macromolecular crystallography. Recent research at Stanford University has led to a new x-ray source that will have a major impact on protein structure determination for health care. The Compact Light Source (CLS) is a breakthrough technology that offers a tunable, tabletop x-ray source that could be used like an x-ray beamline at a large light source. The compact size is achieved through the marriage of a laser and a miniature electron storage ring. The photon flux on a sample will be comparable to many synchrotron beamlines. The overall goals of this proposal are to first engineer, then prototype, and finally demonstrate the performance of the CLS. In Phase I, we will test the laser system and design the electron storage ring. In Phase II, we will build the storage ring, integrate the laser system, and demonstrate x-ray production. The CLS will also provide the foundation for future x-ray applications in the health care field. With the CLS, clinical applications such as non-invasive coronary angiography, diffraction-enhanced imaging, and improved cancer detection could be moved from the laboratory into hospitals throughout the nation.

描述（由申请人提供）：同步辐射源的强烈X射线对科学和技术，尤其是大分子晶体学产生了革命性的影响。斯坦福大学的最新研究导致了一种新的X射线来源，该来源将对蛋白质结构的卫生保健产生重大影响。紧凑型光源（CLS）是一种突破性的技术，可提供可调的桌面X射线源，可以像大型光源一样使用X射线梁线。紧凑的大小是通过激光和微型电子存储环实现的。样品上的光子通量将与许多同步加速器束线相媲美。该提案的总体目标是首先工程师，然后是原型，最后证明CLS的性能。在第一阶段，我们将测试激光系统并设计电子存储环。在第二阶段，我们将构建存储环，集成激光系统并演示X射线产生。 CLS还将为医疗保健领域的未来X射线应用提供基础。借助CLS，临床应用，例如非侵入性冠状动脉造影，衍射增强的成像和改善的癌症检测，可以从实验室转移到全国各地的医院。