Continuous Wave Electron Paramagnetic Resonance Imaging

连续波电子顺磁共振成像

• 批准号: 6952063
• 负责人: Michael Lee
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6952063
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; contrast media; electron spin resonance spectroscopy; free radicals; functional magnetic resonance imaging; image processing; oxidative stress; oximetry; technology /technique development

Project 3: Continuous Wave Electron Paramagnetic Resonance Imaging. This technique provides non-invasive assessment of tissue/tumor redox status using redox sensitive paramagnetic contrast agents called nitroxides. We have now examining new molecules as reporters of oxidative stress, which are precursors of nitroxides and are converted to the corresponding nitroxide by oxidation with reactive oxygen species. Such oxidation should provide information on tissue oxidative stress. Instrumentation is also being developed to provide detection at higher frequencies to give enhanced sensitivity and spatial resolution.

项目 3：连续波电子顺磁共振成像。 该技术使用氧化还原敏感的顺磁造影剂（称为硝基氧）对组织/肿瘤氧化还原状态进行非侵入性评估。我们现在正在研究作为氧化应激报告者的新分子，它们是硝基氧的前体，并通过活性氧的氧化转化为相应的硝基氧。这种氧化应该提供有关组织氧化应激的信息。 仪器也正在开发中，以提供更高频率的检测，以提高灵敏度和空间分辨率。