Vertical Low Tesla Broadband MRI

垂直低特斯拉宽带 MRI

• 批准号: 7389060
• 负责人: ERIC Alfred HOFFMAN
• 金额: $ 50万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2011-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7389060
• 关键词: Applications Grants; Arthritis; Atlases; Back Pain; Biomechanics; Biomedical Engineering; Braces-Orthopedic appliances; Breathing; Condition; Congenital Hip Dislocation; Contrast Media; Development; Diagnostic radiologic examination; Discipline; Disease; Engineering; Equipment; Force of Gravity; Funding; Gases; Grant; Hour; Human; Image; Intervention; Ionizing radiation; Iowa; Joints; Ligaments; Lung; Lung diseases; Magnetic Resonance; Magnetic Resonance Imaging; Medicine; Movement; Musculoskeletal; Nature; Orthopedics; Pathology; Patients; Play; Posture; Process; Protons; Public Health; Pump; Research; Research Personnel; Respiratory physiology; Role; Skeletal system; Staging; Structure; System; Therapeutic Effect; Translational Research; United States National Institutes of Health; Universities; Vertebral column; Work; base; bioimaging; college; experience; feeding; instrumentation; lung imaging; multidisciplinary; scoliosis; simulation; soft tissue

DESCRIPTION (provided by applicant): This is a shared instrumentation grant proposal requesting the purchase of a low Tesla vertically oriented open magnetic resonance imaging system with broad band capabilities (vertical MRI). A vertical imaging system will allow a group of NIH investigators to image the Lung and Orthopedic structures in a vertical orientation so as to evaluate these systems under the gravity loading conditions experienced during most waking hours. MRI has the advantage that it can perform imaging without the need for ionizing radiation (this is particularly important if repeated studies are required or where young patients are investigated). Furthermore, a vertical open system is significantly more patient friendly, both in terms of accessibility and in terms of easier breathing for symptomatic (dyspnoeic) patients. This multinuclear system will allow studies of the lungs using both fast proton imaging (for instance to assess the diaphragmatic pump) and through the application of hyperpolarized nobles gases as contrast agents (with their inherent information on microstructure and regional lung function). It is intended that both normal and pathophysiological conditions will be studied. The work will not only allow imaging parameters to be assessed, but will also feed this information on airway flow simulations and for study of strain relationships, which all may play a role in disease development as well as for the invention of new therapy approaches. Other body applications will initially focus on spine and significant orthopedic conditions, including (but not limited to) effects of gravity on scoliosis and posture, and such conditions as congenital hip dysplasia, premature osteo-arthritis due to joint mal-alignment and to study therapeutic effects of braces in scoliosis and physical approaches to back pain. Clearly, musculoskeletal conditions are significantly influenced by gravity. However, study of these phenomena is notoriously difficult and crude, mainly relying on plain radiography. The advanced imaging capabilities of MRI will allow study of soft tissues (such as ligaments) and variable joint movements during loading. This project responds very well to the NIH's new focus on biomedical imaging and bioengineering, translational research and the need for multiple disciplines to work together. The addition of this equipment to the research capabilities at Iowa will significantly aid a group of NIH funded researchers, likely leading to further interactions between a multidisciplinary array of collaborators, while it will also have an impact on at least three Colleges within the University of Iowa (Medicine, Engineering, and Public Health). Significance to Public Health: This grant request is seeking to gain funding for the acquisition of a vertical magnetic resonance scanner which will allow us to establish within our growing imaging-based atlas of the normal human lung, information which show how the normal lung is structured and functions in the upright body posture. The normative lung atlas is an important first step in detecting early abnormalities and in understanding disease processes. New interventions to lung disease must start at an early stage of the disease process. The requested scanner will also allow us to evaluate the body's support structure with it loaded by gravity. It is critical to evaluate the skeletal system fully loaded if we are to understand the biomechanical nature of orthopedic-related pathology.

描述（由申请人提供）：这是一项共享仪器赠款提案，要求购买具有宽带功能（垂直MRI）的垂直面向特斯拉的开放式磁共振成像系统。垂直成像系统将允许一组NIH研究人员在垂直方向上成像肺和骨科结构，以便在大多数清醒时间经历的重力负载条件下评估这些系统。 MRI的优点是它可以执行成像而无需电离辐射（如果需要重复研究或研究年轻患者的情况，这一点尤其重要）。此外，垂直开放系统在可及性方面和呼吸更容易呼吸（呼吸困难）患者方面都更加友好。该多核系统将允许使用快速质子成像（例如评估diaphragmatic Pump）和通过将超极化贵族气体作为对比剂（其固有的有关微结构和区域肺功能的固有信息）对肺进行研究。旨在研究正常生理状况和病理生理状况。这项工作不仅可以评估成像参数，而且还将提供有关气道流量模拟和研究应变关系的信息，这些信息可能在疾病发展以及新治疗方法的发明中发挥作用。最初，其他身体应用将集中在脊柱和重要的骨科状况上，包括（但不限于）重力对脊柱侧弯和姿势的影响，以及先天性髋关节发育不良，过早的骨关节炎等疾病，造成骨杆菌的治疗效果，以使脊柱质症和物理疼痛对后疼痛进行治疗。显然，肌肉骨骼条件受重力的显着影响。然而，众所周知，对这些现象的研究主要依赖于普通的X射线照相。 MRI的先进成像功能将允许在装载过程中研究软组织（例如韧带）和可变的关节运动。该项目对NIH对生物医学成像和生物工程，翻译研究以及多个学科合作的需求的新重点很好。在爱荷华州的研究能力中增加了这种设备将大大帮助一群NIH资助的研究人员，这可能会导致跨学科合作者之间的进一步互动，而这也将对爱荷华大学（医学，工程和公共卫生）的至少三所学院产生影响。 对公共卫生的意义：该赠款请求正在寻求获得垂直磁共振扫描仪的资金，这将使我们能够在正常的人类肺的基于成像的基质中建立，这些信息显示了正常肺是结构化并在正直身体姿势中起作用的信息。规范性肺地图集是检测早期异常和理解疾病过程的重要第一步。对肺部疾病的新干预必须从疾病过程的早期开始。请求的扫描仪还将允许我们通过重力加载它来评估身体的支撑结构。如果我们要了解与骨科相关病理的生物力学性质，评估骨骼系统的骨骼系统至关重要。