Overhauser Enhanced Magnetic Resonance Imaging (OMRI)

奥豪瑟增强磁共振成像 (OMRI)

• 批准号: 6952062
• 负责人: Michael Lee
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6952062
• 关键词: bioimaging /biomedical imaging; cell line; contrast media; neoplastic cell; nuclear magnetic resonance spectroscopy; perfusion; technology /technique development

Project 2: Overhauser enhanced Magnetic Resonance Imaging. (OMRI) We have examined several tumor models in mice to evaluate the image enhancement profiles. Different tumor types were grown in mice and OMRI experiments were carried out using Oxo 63 as the contrast agent when tumors were at the size of 1 ml. Enhancement profiles were found to be significantly varied in the tumors examined. The melanoma cell line B16 exhibited the highest enhancement where as the SCC cell line (squamous cell carcinoma) exhibited the least enhancement. Other cell lines such as the RIF-1, HT-29 exhibited intermediate enhancement. Additional experiments with conventional contrast enhanced MRI using Gd3+-DTPA on these animals with different tumors showed time -intensity profiles in images which had different behavior in each tumor type tested. Histologic studies quantitating the microvessel density in tumors are proposed to be carried out to study the dependence of image enhancement vs tumor perfusion.

项目 2：Overhauser 增强型磁共振成像。 （开放式磁共振成像） 我们检查了几种小鼠肿瘤模型以评估图像增强曲线。在小鼠体内生长不同类型的肿瘤，当肿瘤大小为1ml时，使用Oxo 63作为造影剂进行OMRI实验。发现所检查的肿瘤的增强特征存在显着差异。黑色素瘤细胞系 B16 表现出最高的增强，而 SCC 细胞系（鳞状细胞癌）表现出最低的增强。其他细胞系如 RIF-1、HT-29 表现出中等增强。使用 Gd3+-DTPA 对这些患有不同肿瘤的动物进行常规对比增强 MRI 的其他实验显示，图像中的时间强度分布在每种测试的肿瘤类型中具有不同的行为。建议进行定量肿瘤中微血管密度的组织学研究，以研究图像增强与肿瘤灌注的依赖性。