A Portable Auto-Calibrating Micro-SPECT Imager

便携式自动校准微型 SPECT 成像仪

• 批准号: 6779883
• 负责人: FRANK P DIFILIPPO
• 金额: $ 7.52万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6779883
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; diagnosis design /evaluation; diagnosis quality /standard; evaluation /testing; phantom model; portable biomedical equipment; single photon emission computed tomography; three dimensional imaging /topography

DESCRIPTION (provided by applicant): Non-invasive imaging of small animals, particularly molecular imaging (SPECT and PET) using radioactive tracers, has emerged as a valuable tool in biomedical research. Because of the specialized hardware required, the growth of micro-SPECT and micro-PET imaging has been limited mainly to dedicated research facilities with the funds and space to accommodate these devices. At clinical facilities, such resources are less available. However, SPECT cameras are widely employed for clinical imaging and could be used after hours by researchers for small animal imaging. Of particular interest are pinhole micro-SPECT imagers using clinical gamma camera detectors. Prior research on pinhole micro-SPECT has shown that the high magnification factor from pinhole collimation allows 1-2 mm spatial resolution to be attained. Previously published work on pinhole micro-SPECT has involved surplus gamma cameras dedicated for research use, with specialized attached hardware and separate calibration procedures. However, these characteristics prevent such designs from being practical for use in a clinical environment. In the proposed work, an innovative micro-SPECT imager with several key features will be developed to overcome these limitations. Our micro-SPECT will be truly portable. The design uses integrated pinhole apertures and does not require specialized mounting hardware, since it is placed directly on the patient imaging table. Our micro-SPECT will also be auto-calibrating. The mechanical alignment is computed directly from the scan data, and the alignment parameters are incorporated into the 3D reconstruction algorithm. In our proposed project, we will develop, optimize, and characterize the performance of a micro-SPECT imager based on this design. Because of these unique features (truly portable and auto-calibrating), our device will enable practical micro-SPECT imaging on conventional clinical gamma cameras, either after hours or during breaks in the clinical schedule. Furthermore, it would be possible for institutions to own multiple micro-SPECT imagers of our design, since the resources required for scale-up are minimal. As a result of this work, several other planned pre-clinical research projects at our institution will benefit directly from the availability of micro-SPECT imaging. Our work may also lead to a commercial product for ultra-low cost micro-SPECT imaging that would benefit many other researchers.

描述（由申请人提供）： 对小动物的非侵入性成像，尤其是使用放射性示踪剂的分子成像（SPECT和PET），已成为生物医学研究中的宝贵工具。 由于需要专门的硬件，因此微光谱和微型PET成像的增长主要限于专门的研究设施，并提供资金和空间以容纳这些设备。 在临床设施中，这种资源较少。 但是，SPECT摄像机被广泛用于临床成像，研究人员可以在小时后用于小动物成像。 特别有趣的是使用临床伽马摄像头探测器的针孔微光谱成像器。 针孔微光谱的先前研究表明，针孔准直的高放大因子允许达到1-2 mM的空间分辨率。 先前发表的有关针孔微光谱的工作涉及专门用于研究用途的多余伽马相机，并具有专门的附加硬件和单独的校准程序。 但是，这些特征阻止了此类设计在临床环境中使用。 在拟议的工作中，将开发一个具有多个关键特征的创新微光谱成像仪来克服这些局限性。 我们的微型光谱将是真正的便携式。 该设计使用集成的针孔孔，并且不需要专门的安装硬件，因为它直接放置在患者成像台上。 我们的微光谱也将自动校准。 机械比对直接根据扫描数据计算，并将对齐参数纳入3D重建算法。 在我们提出的项目中，我们将根据此设计开发，优化和表征微观影像师的性能。 由于这些独特的功能（真正的便携式和自动校准），我们的设备将在下班后或在临床时间表中休息期间对常规临床伽马相机进行实用的微光谱成像。 此外，由于规模所需的资源很少，因此机构有可能拥有我们设计的多个微光谱成像器。 这项工作的结果是，我们机构的其他一些计划的临床前研究项目将直接从微观成像的可用性中受益。 我们的工作还可能导致用于超低成本微光谱成像的商业产品，这将使许多其他研究人员受益。