Auto-calibrating portable low-cost micro-SPECT/CT

自动校准便携式低成本微型 SPECT/CT

• 批准号: 7139850
• 负责人: FRANK P DIFILIPPO
• 金额: $ 16.99万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-25 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7139850
• 关键词: clinical research; drug discovery /isolation; head; molecular /cellular imaging; performance

DESCRIPTION (provided by applicant): We propose to develop a novel ultra-low cost portable device for micro-SPECT/CT using clinical gamma camera detectors. Molecular imaging using micro-SPECT has emerged as a valuable tool for pre-clinical research. The ability to image small animals in-vivo and non-invasively at the molecular level with spatial resolution of 1 mm or better has many research applications in cancer, molecular cardiology, neurology, and drug discovery. The importance of micro-SPECT to research is underscored by the emergence of dedicated small animal scanners in the commercial market. However, the high costs associated with these scanners have limited this technique to established and well-funded laboratories. In our previous work, we developed a practical standalone device to be used in conjunction with a clinical gamma camera. This device is placed directly on the patient table, relying on our "auto-calibration" technique (simultaneous acquisition of emission data and point source marker data) to achieve high resolution without requiring lengthy set-up time for alignment and calibration procedures. A main disadvantage was that this previous design required the animal to be rotated in a vertical orientation, which is far from ideal. Our new proposed second-generation device allows the animal to be stationary and horizontal while preserving all the low-cost advantages of a standalone device. Our preliminary experiments have demonstrated that the auto-calibration technique is robust and accurate for this new and more complex geometry. Our first aim is to design and develop this new device and characterize its micro-SPECT performance using a standard dual-head SPECT camera. Our second aim is to acquire data on a clinical SPECT/CT scanner to produce co-registered micro-SPECT and CT images. Although the CT images do not have ultra-high spatial resolution, they are sufficient for anatomic mapping and attenuation correction of the micro-SPECT data. Our third aim is to optimize the performance through improvements in count sensitivity, image reconstruction, quantitative accuracy, and ease of use. With an estimated total manufacturing cost of under $20K, and since our device is standalone, practical, and inherently compatible with nearly all models of SPECT cameras, the long-term goal of commercialization is very feasible. Many laboratories could then benefit from this device for micro-SPECT and micro-SPECT/CT.

描述（由申请人提供）：我们建议使用临床伽马摄像头探测器开发一种新型的超低成本便携式设备，用于微光谱/CT。使用微光谱的分子成像已成为临床前研究的宝贵工具。在分子水平上以1 mm或更高的空间分辨率在分子水平上对小动物进行对小动物进行成像的能力，在癌症，分子心脏病学，神经病学和药物发现方面有许多研究应用。小光谱对研究的重要性是由于商业市场中专用的小动物扫描仪的出现而强调了。但是，与这些扫描仪相关的高成本将这项技术限制在建立且资金充足的实验室中。在以前的工作中，我们开发了一种实用的独立设备，该设备与临床伽马相机结合使用。该设备直接放置在患者表上，依靠我们的“自动校准”技术（同时获取发射数据和点源标记数据），以实现高分辨率，而无需长时间的安装时间进行对齐和校准程序。一个主要的缺点是，以前的设计要求将动物以垂直方向旋转，这远非理想。我们新提出的第二代设备使动物可以保持静止和水平，同时保留了独立设备的所有低成本优势。我们的初步实验表明，对于这种新的，更复杂的几何形状，自动校准技术是强大而准确的。我们的第一个目的是设计和开发这种新设备，并使用标准双头SPECT摄像头来表征其微光谱性能。我们的第二个目的是获取有关临床SPECT/CT扫描仪的数据，以产生共注册的微光谱和CT图像。尽管CT图像没有超高的空间分辨率，但它们足以进行解剖学映射和微光谱数据的衰减校正。我们的第三个目标是通过改善计数灵敏度，图像重建，定量准确性和易用性来优化性能。估计的总制造成本不到20万美元，并且由于我们的设备是独立的，实用的，并且与几乎所有SPECT摄像机的型号固有兼容，因此商业化的长期目标是非常可行的。然后，许多实验室可以从该设备中受益于微光谱和微光谱/CT。