Auto-calibrating portable low-cost micro-SPECT/CT

自动校准便携式低成本微型 SPECT/CT

• 批准号: 7280832
• 负责人: FRANK P DIFILIPPO
• 金额: $ 16.9万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-25 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7280832
• 关键词: Anatomy; Anesthesia procedures; Animal Experimentation; Animals; Applications Grants; Area; Beds; Biological Process; Calibration; Cardiology; Clinic; Clinical; Collimator; Compatible; Complex; Computer software; Count; Custom; Data; Data Analyses; Devices; Disadvantaged; Disease; Disease Progression; Equipment; Freedom; Funding; Gamma Cameras; Generations; Goals; Head; Hour; Hybrids; Image; In Vitro; Institution; Label; Laboratories; Malignant Neoplasms; Maps; Marketing; Mechanics; Methods; Modality; Modeling; Molecular; Motion; Nature; Neurology; Ocular orbit; Patients; Performance; Physiological; Positron-Emission Tomography; Procedures; Process; Radio; Range; Research; Research Institute; Research Personnel; Research Project Grants; Resolution; Rodent; Scanning; Solutions; Source; Staging; Standards of Weights and Measures; Stress; Study Section; System; Techniques; Technology; Testing; Time; Tomography, Computed, Scanners; United States National Institutes of Health; Visual; Work; attenuation; base; commercialization; cost; data acquisition; design; detector; drug discovery; image reconstruction; improved; in vivo; innovation; interest; molecular imaging; monitoring device; novel; oncology; platform-independent; pre-clinical research; programs; research study; single photon emission computed tomography; tool

DESCRIPTION (provided by applicant): We propose to develop a novel ultra-low cost portable device for micro-SPECT/CT using clinical gamma camera detectors. Molecular imaging using micro-SPECT has emerged as a valuable tool for pre-clinical research. The ability to image small animals in-vivo and non-invasively at the molecular level with spatial resolution of 1 mm or better has many research applications in cancer, molecular cardiology, neurology, and drug discovery. The importance of micro-SPECT to research is underscored by the emergence of dedicated small animal scanners in the commercial market. However, the high costs associated with these scanners have limited this technique to established and well-funded laboratories. In our previous work, we developed a practical standalone device to be used in conjunction with a clinical gamma camera. This device is placed directly on the patient table, relying on our "auto-calibration" technique (simultaneous acquisition of emission data and point source marker data) to achieve high resolution without requiring lengthy set-up time for alignment and calibration procedures. A main disadvantage was that this previous design required the animal to be rotated in a vertical orientation, which is far from ideal. Our new proposed second-generation device allows the animal to be stationary and horizontal while preserving all the low-cost advantages of a standalone device. Our preliminary experiments have demonstrated that the auto-calibration technique is robust and accurate for this new and more complex geometry. Our first aim is to design and develop this new device and characterize its micro-SPECT performance using a standard dual-head SPECT camera. Our second aim is to acquire data on a clinical SPECT/CT scanner to produce co-registered micro-SPECT and CT images. Although the CT images do not have ultra-high spatial resolution, they are sufficient for anatomic mapping and attenuation correction of the micro-SPECT data. Our third aim is to optimize the performance through improvements in count sensitivity, image reconstruction, quantitative accuracy, and ease of use. With an estimated total manufacturing cost of under $20K, and since our device is standalone, practical, and inherently compatible with nearly all models of SPECT cameras, the long-term goal of commercialization is very feasible. Many laboratories could then benefit from this device for micro-SPECT and micro-SPECT/CT.

描述（由申请人提供）：我们建议开发一种新型超低成本便携式设备，用于使用临床伽马相机探测器的微型 SPECT/CT。使用微型 SPECT 的分子成像已成为临床前研究的宝贵工具。以 1 毫米或更好的空间分辨率在分子水平上对小动物体内进行非侵入性成像的能力在癌症、分子心脏病学、神经病学和药物发现方面具有许多研究应用。商业市场上专用小动物扫描仪的出现凸显了微型 SPECT 对研究的重要性。然而，与这些扫描仪相关的高成本限制了这种技术只能应用于成熟且资金充足的实验室。在我们之前的工作中，我们开发了一种实用的独立设备，可与临床伽玛相机结合使用。该设备直接放置在患者台上，依靠我们的“自动校准”技术（同时采集发射数据和点源标记数据）来实现高分辨率，而不需要漫长的设置时间来进行对准和校准程序。主要缺点是先前的设计要求动物以垂直方向旋转，这远非理想。我们新提出的第二代设备允许动物保持静止和水平状态，同时保留独立设备的所有低成本优势。我们的初步实验表明，自动校准技术对于这种新的、更复杂的几何形状来说是稳健且准确的。我们的首要目标是设计和开发这种新设备，并使用标准双头 SPECT 相机表征其微型 SPECT 性能。我们的第二个目标是获取临床 SPECT/CT 扫描仪的数据，以生成共同配准的显微 SPECT 和 CT 图像。尽管CT图像不具有超高空间分辨率，但足以用于显微SPECT数据的解剖测绘和衰减校正。我们的第三个目标是通过提高计数灵敏度、图像重建、定量准确性和易用性来优化性能。预计总制造成本低于 2 万美元，而且由于我们的设备是独立的、实用的，并且本质上与几乎所有型号的 SPECT 相机兼容，因此商业化的长期目标是非常可行的。许多实验室可以从该微型 SPECT 和微型 SPECT/CT 设备中受益。