Gradient Arrays for High Performance Extended FOV MRI

用于高性能扩展 FOV MRI 的梯度阵列

• 批准号: 6830017
• 负责人: DENNIS L PARKER
• 金额: $ 18.68万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6830017
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; biomedical equipment safety; biophysics; clinical biomedical equipment; clinical research; computational biology; computational neuroscience; computer simulation; human subject; image enhancement; magnetic resonance imaging; mathematics; neurons; sensory signal detection; sensory thresholds; technology /technique development

DESCRIPTION (provided by applicant): This project will design, construct, and evaluate a prototype novel gradient array system for extended field of view imaging in magnetic resonance imaging. The gradient design consists of novel repetitions of the longitudinal and transverse gradients to create multiple non-adjacent imaging regions. Imaging is performed in the regions where the applied field gradients are linear. Just as the Maxwell pair (composed of two coaxial coils with alternating currents) can be used to generate a Z-gradient to perform imaging over one region, a Maxwell triplet (composed of three coils with alternating currents) might be used to perform image acquisition over 2 non-contiguous regions of linear field variation and thereby improve imaging efficiency. To acquire image data from the central region of non-linear field variation requires a 2nd Maxwell array which overlaps with the first array such that the linear region(s) of the 2nd array are positioned over the central non-linear I region of the first array. Transverse gradient arrays for multiple region imaging will be designed in a similar manner. In the R21 phase we will use numerical methods and computer simulations to investigate the design and predict the performance of such gradient arrays, including efficiency, slew rate, homogeneity, and power requirements as a function of current distribution. We will also study the issues of gradient overlap, transmit and receive RF coils, and pulse sequence design to obtain contiguous imaging regions. In the R33 phase, we will use the designs from the R21 phase to construct a prototype insert gradient system and the RF coils required for multiple region imaging. We will test the gradient arrays and RF coils at various stages of production. We will also construct a whole-body composite gradient array and perform detailed nerve stimulation studies. This novel design will allow complete utilization of all existing high performance pulse sequences. It will also allow the development of new pulse sequences that utilize the complete hardware capabilities to simultaneously attain increased gradient performance, increased imaging field of view, and decreased nerve stimulation.

描述（由申请人提供）： 该项目将设计，构建和评估一个原型新型梯度阵列系统，以用于磁共振成像中的视野成像。梯度设计由纵向和横向梯度的新重复组成，以创建多个非染色成像区域。成像是在施加的场梯度是线性的区域进行的。正如麦克斯韦对（由两个同轴线圈与交替电流组成）可用于生成z级别以在一个区域上执行成像一样，麦克斯韦三重态（由三个带有交替电流的线圈组成）可用于执行图像审查超过2个线性场变化的不连续区域，从而提高了成像效率。要从非线性场变化的中央区域获取图像数据，需要第二个麦克斯韦阵列，该数组与第一个数组重叠，以使第二个数组的线性区域位于第一个中央非线性I区域，大批。多个区域成像的横向梯度阵列将以类似的方式设计。 在R21阶段，我们将使用数值方法和计算机仿真来研究设计并预测此类梯度阵列的性能，包括效率，回避率，同质性和功率要求，这是当前分布的函数。我们还将研究梯度重叠，传输和接收RF线圈以及脉冲序列设计的问题，以获得连续的成像区域。在R33阶段，我们将使用R21相的设计来构建原型插入梯度系统和多个区域成像所需的RF线圈。我们将在生产的各个阶段测试梯度阵列和RF线圈。我们还将构建一个全身复合梯度阵列并进行详细的神经刺激研究。这种新颖的设计将允许对所有现有的高性能脉冲序列进行完全利用。它还将允许开发使用完整的硬件功能的新脉冲序列，以同时达到梯度性能提高，视野增加了，并减少了神经刺激。

项目成果

Superelliptical insert gradient coil with a field-modifying layer for breast imaging.

具有用于乳腺成像的场修改层的超椭圆插入梯度线圈。

• DOI: 10.1002/mrm.22639
• 发表时间: 2011
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Moon,SungM;Goodrich,KCraig;Hadley,JRock;Kim,Seong-Eun;Zeng,GengshengL;Morrell,GlenR;McAlpine,MatthewA;Chronik,BlaineA;Parker,DennisL
• 通讯作者: Parker,DennisL