Improved imaging of carotid plaque using high-resolution, motion-corrected 3D MRI

使用高分辨率运动校正 3D MRI 改进颈动脉斑块成像

• 批准号: 9334297
• 负责人: DENNIS L PARKER
• 金额: $ 59万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-17 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9334297
• 关键词: Algorithms; Anatomy; Angiography; Arterial Fatty Streak; Caliber; Cardiac; Carotid Artery Plaques; Carotid Endarterectomy; Carotid Stenosis; Clinic; Clinical; Clinical Management; Coupled; Data; Deglutition; Detection; Development; Diagnostic; Diffusion Magnetic Resonance Imaging; Disease; Evaluation; Foundations; Future; Goals; Head; Head and neck structure; Hemorrhage; Histology; Image; Inflammation; Location; Magnetic Resonance Imaging; Measurement; Measures; Methods; Monitor; Motion; Neck; Necrosis; Patients; Performance; Physiologic pulse; Positioning Attribute; Protocols documentation; RF coil; Radial; Research; Resolution; Risk; Risk Factors; Schedule; Slide; Societies; Stenosis; Stroke; Thick; Ultrasonography; Work; X-Ray Computed Tomography; clinically relevant; cohort; contrast enhanced; cost; density; design; high resolution imaging; imaging modality; improved; in vivo; individual patient; innovation; novel; performance tests; prevent; prisma; public health relevance; reconstruction; respiratory; temporal measurement; treatment effect

 DESCRIPTION (provided by applicant): Our goal in this project is to overcome major barriers preventing MRI from being the clinical standard for carotid disease evaluation. Carotid MRI is unique in that it has the potential to accurately measure vulnerable plaque markers in addition to the clinically relevant measurement of percent diameter stenosis. In addition to carotid stenosis, studies using MRI in the research setting have found that carotid intraplaque inflammation (IPI), intraplaque hemorrhage (IPH), necrotic core (NC), and fibrous cap (FC) thickness and disruption are important stroke risk factors. Although MRI has the potential to measure these factors, major barriers still exist to using carotid MRI in the clinical setting. These include 1) he lack of a coil specific to the anatomic location of the carotid bifurcation in all patients and 2) he lack of high-resolution MRI sequences to accurately measure lumen, stenosis, and plaque components in the presence of respiratory, cardiac, and swallowing motion. In this project we will: 1) develop a novel carotid imaging coil with modular interchangeable arrays on formers that match the range of patient neck anatomy encountered; 2) develop innovative pulse sequences to accurately measure carotid lumen, stenosis and plaque components; 3) develop pulse sequence methods and reconstruction algorithms to detect and correct motion-corrupted measurements; and 4) validate these results by comparison with histology. The development of tailor-made subject fitting RF coils will increase SNR and allow higher spatial and temporal resolution. This increased SNR from the modular coils coupled with motion- robust sequences will increase accuracy of identifying in-vivo plaque components. This will lay the foundation for future studies using carotid MRI to optimally characterize stroke risk and monitor treatment effects geared toward decreasing IPI, IPH, NC, and stabilizing the FC. These methods that conveniently, consistently, and accurately depict carotid lumen and plaque components will overcome the major barriers to the use of MRI as the clinical standard in characterizing carotid disease. This will facilitate the transition of carotid MRI from the research setting where MRI methods have been developed to the general clinic where benefit to the individual patient will be obtained and costs to society will ultimately be reduced.

 描述（由适用提供）：我们在该项目中的目标是克服主要障碍，以防止MRI成为颈动脉疾病评估的临床标准。 Carotid MRI的独特之处在于，除了对直径百分比狭窄的临床相关测量外，它具有准确测量脆弱的斑块标记的潜力。除颈动脉狭窄外，在研究环境中使用MRI的研究还发现，颈动脉内注射（IPI），内部出血（IPH），坏死核心（NC）和纤维帽（FC）厚度（FC）厚度和破坏是重要的中风风险因素。尽管MRI有可能衡量这些因素，但在临床环境中仍存在主要障碍。其中包括1）他缺乏针对所有患者颈动脉分叉解剖位置的线圈，2）在存在呼吸道，心脏和吞咽运动的情况下，他缺乏高分辨率MRI序列，无法准确测量腔，狭窄，狭窄和斑块成分。在这个项目中，我们将：1）开发一个新型的颈动脉成像线圈，并在符合患者颈部解剖学范围的形成器上具有模块化的可互换阵列； 2）开发创新的脉冲序列，以准确测量颈动脉腔，狭窄和斑块成分； 3）开发脉冲序列方法和重建算法，以检测和纠正运动腐败测量； 4）与组织学比较验证这些结果。量身定制的RF线圈的量身定制受试者的发展将增加SNR，并允许更高的空间和临时分辨率。从模块化线圈加上运动稳定序列的模块线圈中增加了SNR，将提高识别体内斑块成分的精度。这将为未来的研究奠定基础，以最佳的表征中风风险，并监测旨在减少IPI，IPH，NC和稳定FC的治疗效果。这些方法可以方便，一致，准确地描述颈动脉腔和斑块成分，将克服使用MRI作为表征颈动脉疾病的临床标准的主要障碍。这将促进颈动脉MRI从研究环境的过渡，在该环境中，将MRI方法开发到普通诊所，在那里将获得对个别患者的好处，并最终将减少社会成本。