Non-Invasive MRI-Guided HIFU for Breast Cancer Therapy

非侵入性 MRI 引导 HIFU 用于乳腺癌治疗

• 批准号: 8579530
• 负责人: DENNIS L PARKER
• 金额: $ 50.32万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-21 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8579530
• 关键词: Ablation; Acoustics; Address; Adipose tissue; Adverse event; Affect; Algorithms; Animal Model; Animals; Breast; Breast Cancer Treatment; Burn injury; Classification; Deposition; Detection; Devices; Diagnosis; Disease; Engineering; Ensure; Fat necrosis; Fatty acid glycerol esters; Fibroadenoma; Focused Ultrasound Therapy; Foundations; Frequencies; Future; Goals; Human; Human Volunteers; Hybrids; Image; Implant; Life; Local Therapy; Localized Lesion; Magnetic Resonance Imaging; Mammary Gland Parenchyma; Maps; Measurement; Measures; Methods; Modeling; Monitor; Motion; Normal tissue morphology; Organ; Oryctolagus cuniculus; Pain; Patients; Pattern; Phase I Clinical Trials; Physiologic pulse; Population; Predictive Value; Procedures; Property; Protocols documentation; Protons; Radiation; Research; Safety; Scientist; Skin; System; Techniques; Temperature; Tissues; Treatment Efficacy; Ultrasonography; Universities; Update; Utah; Woman; aqueous; base; breast lesion; cancer therapy; college; disability; good laboratory practice; improved; in vivo; innovation; interest; malignant breast neoplasm; medical schools; minimally invasive; new technology; novel; pre-clinical; preclinical study; public health relevance; reconstruction; skin lesion; tumor

DESCRIPTION (provided by applicant): Breast cancer remains an important disease, adversely affecting a large population of women. The number of women diagnosed with breast cancer has continued to rise. While the majority of patients survive the disease, minimizing any disability or disfigurement as a result of treatment is very important to the patient's future qualty of life. Despite more sensitive MRI methods to detect breast lesions and new minimally invasive conservative forms of therapy, there still remains significant room for improvement in both imaging and therapy. MRI-guided high intensity focused ultrasound (MRgHIFU) has the potential to provide completely non-invasive therapy of localized lesions in the breast. This proposal addresses the remaining limitations that keep MRgHIFU from achieving its potential to non-invasively treat localized breast cancer. Building on an innovative breast-specific MRgHIFU system developed in an academic/industrial partnership led by scientists in the Utah Center for Advanced Imaging Research, the College of Engineering, and School of Medicine, this project will validate the system for rapid, efficacious, and safe non-invasive treatment of localized breast lesions with MRgHIFU. The project consists of four Specific Aims: 1) develop patient-specific methods of ultrasound beam aberration correction to improve ultrasound focus localization in the heterogeneous breast; 2) develop efficient methods for temperature measurement in the adipose and aqueous tissues of the heterogeneous breast to properly monitor the MRgHIFU treatment procedure thereby ensuring complete tumor ablation and avoiding unwanted tissue damage; 3) demonstrate safety and efficacy of tumor and treatment margin ablation in an animal model by proving the system can achieve complete ablation in 90% of all subjects without violating safety constraints; and 4) evaluate the developed ultrasound beam aberration correction and temperature measurement techniques in vivo in humans to demonstrate that the developed techniques are effective in human breasts. The innovations proposed in this project are critical for the safe non-invasive treatment of breast cancer with MRgHIFU and will lay the foundation for a successful phase I clinical trial. This new technology will provide a new, non-invasive treatment option for women with localized breast cancer.

描述（由申请人提供）：乳腺癌仍然是一种重要的疾病，对大量女性产生了不利影响。被诊断出患有乳腺癌的妇女数量继续增加。尽管大多数患者能够在疾病中生存，但由于治疗而最大程度地减少了任何残疾或毁容，这对患者的未来生活质量非常重要。尽管更敏感的MRI方法可检测乳腺癌病变和新的微创保守形式的治疗方法，但在成像和治疗方面仍然有很大的改善空间。 MRI引导的高强度聚焦超声（MRGHIFU）具有对乳房中局部病变的完全非侵入性治疗的潜力。该提案解决了剩余的局限性，这些局限性使MRGHIFU无法实现其非侵入性治疗局部乳腺癌的潜力。在犹他州高级成像研究中心，工程学院和医学院的科学家领导的一项学术/工业伙伴关系中，建立在创新的乳房特异性MRGHIFU系统的基础上，该项目将验证该系统的快速，有效且安全的非侵入性对与MrGhghifu的局部乳房病变的无效治疗。该项目由四个特定目的组成：1）开发特定于患者的超声梁像差校正方法，以改善异质乳房中的超声重点定位； 2）开发有效的方法，用于在异质乳房的脂肪和水性组织中进行温度测量，以正确监测MRGHIFU治疗程序，从而确保完全肿瘤消融并避免不必要的组织损伤； 3）通过证明该系统可以在所有受试者的90％的情况下完全消融，而不会违反安全限制，证明了动物模型中肿瘤和治疗边缘消融的安全性和功效； 4）评估人类体内发达的超声梁像差校正和温度测量技术，以证明所发达的技术在人类乳房中有效。该项目中提出的创新对于通过MRGHIFU对乳腺癌进行安全的非侵入性治疗至关重要，并将为成功的I期临床试验奠定基础。这项新技术将为局部乳腺癌女性提供一种新的非侵入性治疗选择。