500MHz Console Upgrade

500MHz 控制台升级

• 批准号: 6582457
• 负责人: BRUCE GANEM
• 金额: $ 31.06万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6582457
• 关键词: biomedical equipment purchase; nuclear magnetic resonance spectroscopy

DESCRIPTION (provided by applicant): In this proposal we request a console upgrade for a Unity 500 MHz NMR Spectrometer manufactured by Varian Associates. The Unity 500 is three generations out of date and the performance no longer meets the needs of the majority of NIH users within the facility. The upgrade will improve the sensitivity, resolution, and reliability of the current instrument allowing for more sophisticated experiments and higher user throughput. The NMR Facility, which has been in existence for 30 years with a Ph.D. level professional NMR spectroscopist as Director, has a long track record of user training, instrument maintenance, and supervision. The Unity 500 MHz instrument user base consists mostly of faculty with a record of continuous NIH support. Beyond the major users, Cornell currently has three minor users whose groups are young and whose PIs will eventually rely on NIH support. These individuals and their students will use the requested instrumentation for a wide range of health-related projects. Professor B. Ganem (PI) is studying the design of new synthetic prodrugs based on the natural product COTC, which would be targeted specifically to prostate tissue, as well as on the synthesis of new inhibitors of glycosphingolipid metabolism; Professor T.P. Begley will use the instrumentation to study modified enzyme substrates, designed inhibitors, products and mechanistic probes; Professor J. Clardy is investigating fungal metabolites exhibiting anticancer, antiviral, and antibiotic activity; Professor B.R. Crane aims to understand how protein structure controls redox- and photochemistry in biological catalysis and signal transduction. Professor G.W. Coates will investigate new methods for the synthesis of architecturally well-defined biodegradable polymers for biomedical use; Prof. D.B. Collum is investigating organolithium solvation and aggregation states using NMR to obtain new insights into synthetically useful lithium reagents; Professor D.T. McQuade will use NMR in designing new synthetic approaches to highly functionalized polymers; Prof. J. Meinwald will investigate the structures of biologically significant molecules involved in chemical communication.

描述（由申请人提供）：在本提案中，我们请求对 Varian Associates 制造的 Unity 500 MHz NMR 波谱仪进行控制台升级。 Unity 500 已经过时了三代，其性能已无法满足设施内大多数 NIH 用户的需求。此次升级将提高当前仪器的灵敏度、分辨率和可靠性，从而实现更复杂的实验和更高的用户吞吐量。 NMR 设施已存在 30 年，拥有博士学位。主任级专业核磁共振波谱学家，在用户培训、仪器维护和监督方面拥有长期的记录。 Unity 500 MHz 仪器用户群主要由具有 NIH 持续支持记录的教师组成。除了主要用户之外，康奈尔大学目前还拥有三个次要用户，这些用户的群体很年轻，其 PI 最终将依赖于 NIH 的支持。这些人和他们的学生将使用所需的仪器进行各种与健康相关的项目。 B. Ganem 教授（PI）正在研究基于天然产物 COTC 的新型合成前药的设计，该药物将专门针对前列腺组织，以及新型鞘糖脂代谢抑制剂的合成；教授贝格利将使用该仪器来研究修饰的酶底物、设计的抑制剂、产品和机制探针； J. Clardy 教授正在研究具有抗癌、抗病毒和抗生素活性的真菌代谢物； B.R.教授Crane 旨在了解蛋白质结构如何控制生物催化和信号转导中的氧化还原和光化学。 G.W.教授科茨将研究合成用于生物医学用途的结构明确的可生物降解聚合物的新方法； D.B.教授Collum 正在使用 NMR 研究有机锂溶剂化和聚集状态，以获得对合成有用的锂试剂的新见解； D.T. McQuade 教授将使用 NMR 设计高功能化聚合物的新合成方法； J. Meinwald 教授将研究参与化学通讯的具有生物学意义的分子的结构。