PharmaScan 70/16 In-Vivo Spectroscopy/Imaging System

PharmaScan 70/16 体内光谱/成像系统

• 批准号: 6803355
• 负责人: Ranu Jung
• 金额: $ 130.96万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6803355
• 关键词: biomedical equipment purchase; nuclear magnetic resonance spectroscopy; respirators

DESCRIPTION (provided by applicant): With recent genetic and molecular advances, small animal (rat/mice) models of human disease have become increasingly important resources for the investigation of the underlying mechanisms of disease. Many traditional investigational approaches require sacrificing the animals for ex vivo tissue and molecular analysis. This prevents the researchers from observing in vivo the natural or perturbed evolution of the processes under study. Additionally, small animal models are becoming increasingly important test beds to investigate the ability of novel implantable miniaturized devices and biomaterials to repair, regenerate or replace the living system. Imaging on the scale of small animals offers an opportunity to noninvasively repeal investigations of biological processes in vivo in the same animal and efficiently test treatments for disease. One approach for bioimaging is to use nuclear magnetic resonance. The ability to perform in vivo imaging and spectroscopy in small animals or large tissue samples is absent at Arizona State University. The gap is further enhanced because of a lack of such a capability in the entire Metropolitan Phoenix Valley area that is home to several excellent clinical and research medical facilities The distance to the closest facility (120 miles) is not conducive to conducting longitudinal chronic studies on large numbers of small animals to support the needs of research in the Phoenix Valley. We request support for a PharmaScan 70116 7.0 Tesla, 90 cm clear bore system from Bruker-Biospin. This is a multipurpose research scanner for high resolution, fast speed, Nuclear Magnetic Resonance 2D and 3D image reconstruction and in vivo spectroscopy. Several investigators would significantly benefit from utilizing this system in their research. The applications would range from assessing effects of chemotherapy for tumors, to developing, testing, and implementing noninvasive, brain-imaging indicators of Alzheimer's Disease (AD) in double transgenic mice containing AD genes, to assessment of CNS neuroplasticity after spinal cord injury or stroke.

描述（由申请人提供）： 随着最近遗传和分子的进步，人类疾病的小动物（大鼠/小鼠）模型已成为研究疾病潜在机制的越来越重要的资源。许多传统的研究方法需要牺牲动物进行离体组织和分子分析。这使得研究人员无法在体内观察所研究过程的自然或扰动演化。此外，小动物模型正成为越来越重要的试验台，用于研究新型可植入微型设备和生物材料修复、再生或替代生命系统的能力。小动物规模的成像提供了一个机会，可以无创地消除对同一动物体内生物过程的研究，并有效地测试疾病的治疗方法。 生物成像的一种方法是使用核磁共振。亚利桑那州立大学不具备对小动物或大型组织样本进行体内成像和光谱分析的能力。由于整个大都会凤凰谷地区缺乏这种能力，差距进一步扩大，该地区拥有多个优秀的临床和研究医疗设施。距最近设施的距离（120 英里）不利于开展纵向慢性研究大量的小动物来支持凤凰谷的研究需求。我们请求 Bruker-Biospin 为 PharmaScan 70116 7.0 Tesla、90 cm 通孔系统提供支持。这是一款多功能研究扫描仪，用于高分辨率、快速、核磁共振 2D 和 3D 图像重建以及体内光谱学。一些研究人员将从在他们的研究中使用该系统中获益匪浅。应用范围包括评估肿瘤化疗的效果，在含有 AD 基因的双转基因小鼠中开发、测试和实施阿尔茨海默病 (AD) 的无创性脑成像指标，以及评估脊髓损伤或中风后的中枢神经系统神经可塑性。