CHEMISTRY OF BIOLOGICAL SYSTEMS

生物系统化学

• 批准号: 6150909
• 负责人: BRUCE GANEM
• 金额: $ 20.78万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6150909
• 关键词: CHEMISTRY; BIOLOGICAL; SYSTEMS

This revised proposal describes plans by sixteen Cornell faculty members to establish a vigorous chemistry-biology interface predoctoral training program which is designed to produce scientists having thorough training in several aspects of "pure" chemistry as well as in scientific disciplines such as structural and bioorganic chemistry, drug design, enzymology and molecular biology (to name just a few) which lie at the interface of chemistry and biology. The proposed project focuses sharply on three main features of the chemistry of biological systems: design, assembly and analysis. The purpose of the plan described herein is to help trainees develop beyond the scope of a typical graduate program in chemistry. In addition to having strong undergraduate training in chemistry, the sixteen students selected for support will further advance their interdisciplinary training by planning their graduate academic work around a core curriculum of courses in areas spanning both chemical and biological disciplines. Moreover each will be completely free to carry out his or her doctoral thesis research in one or more of the laboratories of the sixteen participating faculty. All participating faculty have strong research programs in various aspects of chemistry, which are well-funded by the National Institutes of Health. Nine participating faculty have primary academic appointments in the Department of Chemistry, and five of these chemists are elected members of the field of biochemistry. The overall research interests of participating faculty are broadly distributed over areas of synthetic organic, bioorganic, biophysical and polymer chemistry, as well as such fields as x-ray crystallography, nmr spectroscopy, protein structure and function, enzymology and immunology. While individual research groups are extremely well-equipped to conduct the proposed research, Cornell University maintains a large number of diverse instrument facilities and dedicated research centers which are available to all trainees, Besides attending weekly seminars on relevant topics within the Field of Chemistry and the Division of Biological Sciences at Cornell, trainees will participate in a special interdisciplinary seminar program, with monthly meetings during the academic year when both students and faculty present their work. Trainees will also be exposed to industrial research through internships with interested industrial affiliates as well as through campus seminars and visits by industrial scientists. Thesis research and collaborations in the laboratories of the sixteen participating faculty members prepare trainees for careers in multidisciplinary research at the interface of chemistry and biology.

这份修订后的提案描述了十六名康奈尔大学教职员工的计划 建立强有力的化学-生物学接口博士前培训 旨在培养接受过全面培训的科学家的计划 在“纯”化学以及科学的几个方面 结构化学和生物有机化学、药物设计等学科， 酶学和分子生物学（仅举几例）位于 化学和生物学的界面。拟议的项目重点突出 生物系统化学的三个主要特征：设计、 组装和分析。本文所述计划的目的是 帮助学员超越典型研究生课程的范围进行发展 化学。除了拥有强大的本科培训 化学方面，被选中支持的十六名学生将进一步进步 通过规划研究生学术工作来进行跨学科培训 围绕化学和化学领域的核心课程 生物学科。而且每一个都将完全免费携带 完成他或她的博士论文研究中的一项或多项 十六名参与教师的实验室。所有参加者 教师在化学的各个方面都有强大的研究项目， 这些项目得到了美国国立卫生研究院的大力资助。九 参与的教师在以下领域拥有主要学术任命： 化学系，其中五位化学家当选为院士 属于生物化学领域。总体研究兴趣 参与的教师广泛分布在合成领域 有机、生物有机、生物物理和高分子化学等 X 射线晶体学、核磁共振光谱学、蛋白质结构和 功能、酶学和免疫学。虽然个别研究小组正在 康奈尔大学有能力进行拟议的研究 大学拥有大量多样化的仪器设施和 专门的研究中心可供所有学员使用，此外 每周参加该领域相关主题的研讨会 康奈尔大学化学与生物科学系，实习生 将参加一个特别的跨学科研讨会计划， 学年期间每月举行一次会议，学生和教师双方 展示他们的作品。学员还将接触工业研究 通过与感兴趣的工业附属机构的实习以及 通过校园研讨会和工业科学家的访问。论文 十六个实验室的研究和合作 参与的教师为学员的职业生涯做好准备 化学和生物学交叉领域的多学科研究。