Proteomics: Technologies and Applications

蛋白质组学：技术与应用

• 批准号: 6582024
• 负责人: Ruedi H. Aebersold
• 金额: $ 1.2万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2004-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6582024
• 关键词: meeting /conference /symposium; protein protein interaction; protein structure function; proteomics; travel

DESCRIPTION (provided by applicant) The completion of the genomic sequences of a number of prokaryotic and eukaryotic species has catalyzed new research approaches to study the structure, function and control of biological processes. They are characterized by the systematic, and in many cases, quantitative analysis of all the molecules of a particular type expressed by a cell or tissue. The systematic analysis of proteins has been termed "proteomics." In an initial phase, most of the proteomics efforts were focused on large-scale protein identification. More recently, the objectives and technologies of proteomics have been diversified and expanded. Current proteomics research attempts to systematically and, where applicable, quantitatively determine the many properties of proteins that determine both their biological function and how different proteins interact to control and execute complex biological processes. Specific properties investigated include protein abundance, state of modification, specific activity, interaction with other biomolecules, half-life, subcellular location and structure. Significant current challenges include the development of suitable technologies to determine these properties on a proteome-wide scale, the interpreation of the large amounts of data obtained, and the integration of different types of data into a coherent model describing a biological process. The goal of the meeting is to bring together the leading experts from the different areas of proteomics research to discuss emerging technologies and their applications to biological and clinical research.

描述（由申请人提供） 许多原核和真核物种基因组序列的完成催生了研究生物过程的结构、功能和控制的新研究方法。它们的特点是对细胞或组织表达的特定类型的所有分子进行系统的、并且在许多情况下进行定量分析。 蛋白质的系统分析被称为“蛋白质组学”。 在初始阶段，大多数蛋白质组学工作都集中在大规模蛋白质鉴定上。 最近，蛋白质组学的目标和技术已经多样化和扩展。 当前的蛋白质组学研究试图系统地、在适用的情况下定量确定蛋白质的许多特性，这些特性决定了它们的生物功能以及不同蛋白质如何相互作用以控制和执行复杂的生物过程。 研究的具体特性包括蛋白质丰度、修饰状态、比活性、与其他生物分子的相互作用、半衰期、亚细胞位置和结构。 当前的重大挑战包括开发合适的技术来在蛋白质组范围内确定这些特性，解释所获得的大量数据，以及将不同类型的数据集成到描述生物过程的连贯模型中。 会议的目标是汇集蛋白质组学研究不同领域的领先专家，讨论新兴技术及其在生物和临床研究中的应用。